Effect of electroacupuncture on the MMP-2/9 pathway mediated blood-brain barrier permeability in mice with Parkinson's disease

Effect of electroacupuncture on the MMP-2/9 pathway mediated blood-brain barrier permeability in mice with Parkinson's disease

ABSTRACT: Objective: To investigate the effects of electroacupuncture (EA) on the blood-brain barrier permeability and the regulation of matrix metalloproteinases (MMPs) in the mice with Parkinson's disease (PD). Methods: Forty-eight C57BL/6 mice were randomly assigned into the normal control...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiao-lei ZHANG, Meng-ni HU, Ya-nan LI, Yao WANG, Zhen RONG, Jun MA
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-01-01
Series:	World Journal of Acupuncture - Moxibustion
Subjects:	Parkinson's disease Electroacupuncture Blood-brain barrier Tight junction protein MMP-2 MMP-9
Online Access:	http://www.sciencedirect.com/science/article/pii/S1003525725000029
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Localization Of MMP-2 And MMP-9 In Canine Mammary Gland During Pregnancy
by: Despina Pupaki, et al.
Published: (2014-12-01)

Changes of Serum Concentrations of Alkaline Phosphatase and Metalloproteinase-9 in an Ovariectomized Wistar Rat Model of Osteoporosis
by: Alexander Blagev, et al.
Published: (2017-11-01)

Effect of serum IL-6, CRP, and MMP-9 levels on the efficacy of modified preperitoneal Kugel repair in patients with inguinal hernia
by: Li Lifang, et al.
Published: (2025-04-01)

Regulation, Function, and Expression of Matrix Metalloproteinase-9 in Colon, Lung, and Breast Cancers In Silico and Experimental Methods From Iraqi Metastatic Patients
by: Hamad Hamad Ali, et al.
Published: (2025-06-01)

Predictive value of MMP-2, MMP-9, TIMP-1 in surgical treatment of localized renal cell cancer
by: A. I. Tarasenko, et al.
Published: (2021-06-01)

Pitavastatin reduces intestinal fibrosis in chronic colitis and inhibits colon fibroblast activation by enhancing MMP-9 expression via the IGF-1/IGF-1R pathway
by: Mengran Zhang, et al.
Published: (2025-08-01)

Catalase-encapsulated matrix metalloproteinase-9 responsive nanogels for modulation of inflammatory response and treatment of neutrophilic asthma
by: Xiaoping Guo, et al.
Published: (2025-05-01)

The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis
by: Tuba Talo yildirim, et al.
Published: (2019-09-01)

Hypoxia disrupts human bronchial epithelial barrier integrity via tight junction protein remodeling and enhanced paracellular leakage
by: Jianmin Huang, et al.
Published: (2025-08-01)

The Impact of Helicobacter pylori on Lesion Type and Matrix Metalloproteinase-9 Expression in Laryngeal Tumors
by: Wasan Abdul-elah Bakir, et al.
Published: (2025-04-01)

Imatinib prevents blood-spinal cord barrier disruption by inhibiting PDGFR-mediated JMJD3 expression and activation after spinal cord injury
by: Chan Sol Park, et al.
Published: (2025-07-01)

Unveiling the causative role of promoter variant rs113823671 in MMP7 in gallbladder cancer susceptibility
by: Vinay Jeeyar, et al.
Published: (2025-07-01)

The rs1940475 polymorphism in the MMP8 gene as a protective factor of severe breast cancer
by: N. V. Pavlova, et al.
Published: (2022-09-01)

Polymorphism of angiogenesis regulation factor genes (<i>VEGF/VEGFR</i>), and extracellular matrix remodeling genes (<i>MMP/TIMP</i>), and the levels of their products in extracellular tissues of patients with primary and secondary lymphedema
by: V. I. Konenkov, et al.
Published: (2024-07-01)

Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection
by: Timea Teglas, et al.
Published: (2025-06-01)

Electroacupuncture attenuates retinal ischemia/reperfusion injury by protecting the outer blood-retina barrier via enkephalins activate delta opioid receptor
by: Ping CHEN, et al.
Published: (2025-07-01)

Biomarkers in assessing the vulnerability of atherosclerotic plaques: a narrative review
by: A. N. Kovalskaya, et al.
Published: (2023-07-01)

MMP14 as a central mediator of TGF-β1−induced extracellular matrix remodeling in graves’ orbitopathy
by: Xing Wang, et al.
Published: (2025-07-01)

2,2’- Bipyridine Derivatives Exert Anticancer Effects by Inducing Apoptosis in Hepatocellular Carcinoma (HepG2) Cells
by: Priyanka, et al.
Published: (2024-11-01)

Aspergillusidone G Exerts Anti-Neuroinflammatory Effects via Inhibiting MMP9 Through Integrated Bioinformatics and Experimental Analysis: Implications for Parkinson’s Disease Intervention
by: Fangfang Ban, et al.
Published: (2025-04-01)

Gene Expression of Extracellular Matrix Proteins, MMPs, and TIMPs in Post-Operative Tissues of Chronic Rhinosinusitis Patients
by: Zygimantas Vaitkus, et al.
Published: (2025-04-01)

Protective role of omega-3 polyunsaturated fatty acids supplementation in children and adolescents with bronchial asthma: a 6-month randomized, double-blind, placebo-controlled trial
by: Ebtesam Ahmed Attia, et al.
Published: (2025-07-01)

Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity
by: Guoqing Bao, et al.
Published: (2025-08-01)

MMP3 mediates E2-induced bovine endometrial cell proliferation by releasing HB-EGF
by: Al-Nur Md. Iftekhar RAHMAN, et al.
Published: (2025-07-01)

Gut permeability and osteoarthritis, towards a mechanistic understanding of the pathogenesis: a systematic review
by: Giorgio Guido, et al.
Published: (2021-01-01)

Electroacupuncture stimulation improves pulmonary fibrosis by modulating ferroptosis in rats: multiscale analysis of transcriptome and proteome
by: Yange Tian, et al.
Published: (2025-08-01)

Inhibition of colorectal carcinogenesis by sunitinib malate: disruption of the IL-6/STAT3/c-MYC/TWIST/MMP2 autocrine signaling axis
by: Ling Qian, et al.
Published: (2025-05-01)

Combination of electroacupuncture and Liqi Yangyin formula treatment alleviates cognitive impairment and constipation in D-gal-induced mice via modulation of the brain-gut axis
by: Canwei Xu, et al.
Published: (2025-09-01)

Saxagliptin suppresses degradation of type II collagen and aggrecan in primary human chondrocytes: a therapeutic implication in osteoarthritis
by: Ning Hu, et al.
Published: (2019-12-01)

Integrated analysis of genomic and transcriptomic profiles identified a prognostic immunohistochemistry panel for esophageal squamous cell cancer
by: Yue Yu, et al.
Published: (2020-01-01)

Peri‐Implant Diseases: Enhanced Antibacterial Photodynamic Therapy
by: Hanna Lähteenmäki, et al.
Published: (2025-06-01)

Predictors of heart failure in patients with cardiomyopathies of various origins
by: O. O. Kuznetsova, et al.
Published: (2023-11-01)

Effect of Selective Dentine Pre-Treatment with Butane Tetracarboxylic Acid on Composite-Dentine Bond
by: Nikita Sharma, et al.
Published: (2025-01-01)

Neuregulin-1β, Biomarkers of Inflammation and Myocardial Fibrosis in Heart Failure Patients
by: K. A. Zhbanov, et al.
Published: (2022-11-01)

Electroacupuncture Exerts Anti-Obesity Effects by Affecting the Gut Microbiota and Upregulating Acetic Acid and 5-HT Levels in Obese Rats
by: Zhang J, et al.
Published: (2025-08-01)

Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review
by: Lulu Fu, et al.
Published: (2025-08-01)

Prognostic Value of Urinary Biomarkers in Proteinuria Progression in IgA Nephropathy Patients Treated with Budesonide
by: Christodoulos Keskinis, et al.
Published: (2025-04-01)

Harnessing electroacupuncture: a promising strategy against sleep deprivation-exacerbated post-cardiac arrest brain injury
by: Wenchao Fu, et al.
Published: (2025-08-01)

Accurate Chemogenetics Determines Electroacupuncture Analgesia Through Increased CB1 to Suppress the TRPV1 Pathway in a Mouse Model of Fibromyalgia
by: Huan-Chin Lin, et al.
Published: (2025-05-01)

The SARS-CoV-2 envelope PDZ binding motif acts as a virulence factor disrupting host’s epithelial cell–cell junctions
by: Flavio Alvarez, et al.
Published: (2025-07-01)