Analysis of the overall development trends and hotspots in the research field of the human gut virome
Abstract Background Dysbiosis of the human gut virome is associated with a variety of factors, yet the underlying mechanisms remain poorly understood. This study aims to map the current research trajectory of the human gut virome and propose a strategic framework for future scientific research. Meth...
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BMC
2025-07-01
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| Series: | Virology Journal |
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| Online Access: | https://doi.org/10.1186/s12985-025-02856-x |
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| author | Yidi Zhang Ting Mei Minhui Wang Chunxia Huang Hanzhi Yi Yu Zhan Sen Yang Han Wang Qiulong Yan Ruochun Guo Changming Chen |
| author_facet | Yidi Zhang Ting Mei Minhui Wang Chunxia Huang Hanzhi Yi Yu Zhan Sen Yang Han Wang Qiulong Yan Ruochun Guo Changming Chen |
| author_sort | Yidi Zhang |
| collection | DOAJ |
| description | Abstract Background Dysbiosis of the human gut virome is associated with a variety of factors, yet the underlying mechanisms remain poorly understood. This study aims to map the current research trajectory of the human gut virome and propose a strategic framework for future scientific research. Methods A bibliometric analysis was performed on articles retrieved from the Web of Science (WoS) Core Collection database covering the period 2000 to 2024, utilizing VOSviewer, CiteSpace, and the R software environment. Results Over the past 20 years, the number of published papers and citations in the field of enterovirus research has shown a significant growth trend. This trend is attributed to the breakthrough progress of high-throughput sequencing technology and the iterative upgrade of viral genome databases such as CheckV, which has made the classification resolution of the enterovirus group more accurate and discovered a large number of unknown bacteriophages. Technological innovation has led to a fundamental transformation in the research model, evolving from the traditional single-virus species identification to the multi-omics integrated analysis of virus-host interaction networks. It is worth noting that the existing research shows a distinct feature of "imbalance between dry and wet experiments". Most of the achievements are based on bioinformatics analysis, while the translational medicine research involving virus isolation, culture and functional verification is still in its infancy (accounting for only 25%), especially the mechanism research evidence chain for key scientific issues such as the viral-host molecular interaction mechanism has not yet been completed. Conclusion The progress of enterovirus group research is developing rapidly. However, the species-level taxonomy of a large proportion of newly discovered bacteriophages remains unresolved. Future research must give priority to establishing a comprehensive functional database, and at the same time combine the systematic characterization of viral functions with the study of the mechanism of host-virus interaction to enable bacteriophages to play a role in maintaining human health. |
| format | Article |
| id | doaj-art-df6efb6cf43d4ad393815d2b18670b9c |
| institution | Kabale University |
| issn | 1743-422X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj-art-df6efb6cf43d4ad393815d2b18670b9c2025-08-20T04:01:25ZengBMCVirology Journal1743-422X2025-07-0122111810.1186/s12985-025-02856-xAnalysis of the overall development trends and hotspots in the research field of the human gut viromeYidi Zhang0Ting Mei1Minhui Wang2Chunxia Huang3Hanzhi Yi4Yu Zhan5Sen Yang6Han Wang7Qiulong Yan8Ruochun Guo9Changming Chen10Guizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineGuizhou University of Traditional Chinese MedicineThe Fifth Affiliated Hospital of Southern Medical UniversityPuensum Genetech InstituteGuizhou University of Traditional Chinese MedicineAbstract Background Dysbiosis of the human gut virome is associated with a variety of factors, yet the underlying mechanisms remain poorly understood. This study aims to map the current research trajectory of the human gut virome and propose a strategic framework for future scientific research. Methods A bibliometric analysis was performed on articles retrieved from the Web of Science (WoS) Core Collection database covering the period 2000 to 2024, utilizing VOSviewer, CiteSpace, and the R software environment. Results Over the past 20 years, the number of published papers and citations in the field of enterovirus research has shown a significant growth trend. This trend is attributed to the breakthrough progress of high-throughput sequencing technology and the iterative upgrade of viral genome databases such as CheckV, which has made the classification resolution of the enterovirus group more accurate and discovered a large number of unknown bacteriophages. Technological innovation has led to a fundamental transformation in the research model, evolving from the traditional single-virus species identification to the multi-omics integrated analysis of virus-host interaction networks. It is worth noting that the existing research shows a distinct feature of "imbalance between dry and wet experiments". Most of the achievements are based on bioinformatics analysis, while the translational medicine research involving virus isolation, culture and functional verification is still in its infancy (accounting for only 25%), especially the mechanism research evidence chain for key scientific issues such as the viral-host molecular interaction mechanism has not yet been completed. Conclusion The progress of enterovirus group research is developing rapidly. However, the species-level taxonomy of a large proportion of newly discovered bacteriophages remains unresolved. Future research must give priority to establishing a comprehensive functional database, and at the same time combine the systematic characterization of viral functions with the study of the mechanism of host-virus interaction to enable bacteriophages to play a role in maintaining human health.https://doi.org/10.1186/s12985-025-02856-xGut ViromeBibliometricsPhage therapyTheme EvolutionHotspot Analysis |
| spellingShingle | Yidi Zhang Ting Mei Minhui Wang Chunxia Huang Hanzhi Yi Yu Zhan Sen Yang Han Wang Qiulong Yan Ruochun Guo Changming Chen Analysis of the overall development trends and hotspots in the research field of the human gut virome Virology Journal Gut Virome Bibliometrics Phage therapy Theme Evolution Hotspot Analysis |
| title | Analysis of the overall development trends and hotspots in the research field of the human gut virome |
| title_full | Analysis of the overall development trends and hotspots in the research field of the human gut virome |
| title_fullStr | Analysis of the overall development trends and hotspots in the research field of the human gut virome |
| title_full_unstemmed | Analysis of the overall development trends and hotspots in the research field of the human gut virome |
| title_short | Analysis of the overall development trends and hotspots in the research field of the human gut virome |
| title_sort | analysis of the overall development trends and hotspots in the research field of the human gut virome |
| topic | Gut Virome Bibliometrics Phage therapy Theme Evolution Hotspot Analysis |
| url | https://doi.org/10.1186/s12985-025-02856-x |
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