Identification of replicative aging and inflammatory aging signatures via whole-genome CRISPRi screens
Abstract Background Aging is a major risk factor for chronic diseases and cancer. Cellular aging, particularly in adult stem cells, offers a high-throughput framework for dissecting the molecular mechanisms of aging. Results We perform multiple genome-wide CRISPR interference (CRISPRi) screenings in...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-08-01
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| Series: | Genome Biology |
| Online Access: | https://doi.org/10.1186/s13059-025-03683-7 |
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