Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery
Breast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to cancer treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, the efficacy of these treatments in batt...
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MDPI AG
2024-11-01
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| Series: | Drugs and Drug Candidates |
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| Online Access: | https://www.mdpi.com/2813-2998/3/4/46 |
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| author | Saravanan Alamelu Kamalesh Balakumar Venkatesan Kalist Shagirtha Manoj Kumar Srinivasan Chellasamy Panneerselvam Al Thabiani Aziz Mohammed Ali Alshehri Mohamed Ali Seyed Pugalendhi Pachaiappan |
| author_facet | Saravanan Alamelu Kamalesh Balakumar Venkatesan Kalist Shagirtha Manoj Kumar Srinivasan Chellasamy Panneerselvam Al Thabiani Aziz Mohammed Ali Alshehri Mohamed Ali Seyed Pugalendhi Pachaiappan |
| author_sort | Saravanan Alamelu |
| collection | DOAJ |
| description | Breast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to cancer treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, the efficacy of these treatments in battling BC is often compromised due to the adverse effects they inflict on healthy tissues and organs. In recent times, a range of nanoparticles (NPs) has emerged, exhibiting the potential to specifically target malignant cells while sparing normal cells and organs from harm. This has paved the way for the development of nanoparticle-mediated targeted drug delivery systems, holding great promise as a technique for addressing BC. To increase the efficacy of this new method, several nanocarriers including inorganic NPs (such as magnetic NPs, silica NPs, etc.) and organic NPs (e.g., dendrimers, liposomes, micelles, and polymeric NPs) have been used. Herein, we discuss the mechanism of NP-targeted drug delivery and the recent advancement of therapeutic strategies of organic and inorganic nanocarriers for anticancer drug delivery in BC. We also discuss the future prospects and challenges of nanoparticle-based therapies for BC. |
| format | Article |
| id | doaj-art-df4a05fb43b3463b84737e6445fb1ff0 |
| institution | Kabale University |
| issn | 2813-2998 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Drugs and Drug Candidates |
| spelling | doaj-art-df4a05fb43b3463b84737e6445fb1ff02024-12-27T14:20:16ZengMDPI AGDrugs and Drug Candidates2813-29982024-11-013481383710.3390/ddc3040046Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug DeliverySaravanan Alamelu0Kamalesh Balakumar Venkatesan1Kalist Shagirtha2Manoj Kumar Srinivasan3Chellasamy Panneerselvam4Al Thabiani Aziz5Mohammed Ali Alshehri6Mohamed Ali Seyed7Pugalendhi Pachaiappan8Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, IndiaDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, IndiaDepartment of Biochemistry, St. Joseph’s College of Arts and Science (Autonomous), Cuddalore 607001, Tamilnadu, IndiaDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, IndiaDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi ArabiaDepartment of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamilnadu, IndiaBreast cancer (BC) is the most prevalent form of malignancy among women on a global scale, ranking alongside lung cancer. Presently, conventional approaches to cancer treatment include surgical procedures followed by chemotherapy or radiotherapy. Nonetheless, the efficacy of these treatments in battling BC is often compromised due to the adverse effects they inflict on healthy tissues and organs. In recent times, a range of nanoparticles (NPs) has emerged, exhibiting the potential to specifically target malignant cells while sparing normal cells and organs from harm. This has paved the way for the development of nanoparticle-mediated targeted drug delivery systems, holding great promise as a technique for addressing BC. To increase the efficacy of this new method, several nanocarriers including inorganic NPs (such as magnetic NPs, silica NPs, etc.) and organic NPs (e.g., dendrimers, liposomes, micelles, and polymeric NPs) have been used. Herein, we discuss the mechanism of NP-targeted drug delivery and the recent advancement of therapeutic strategies of organic and inorganic nanocarriers for anticancer drug delivery in BC. We also discuss the future prospects and challenges of nanoparticle-based therapies for BC.https://www.mdpi.com/2813-2998/3/4/46breast cancerinorganic nanoparticlemalignancynanoparticlesorganic nanoparticletargeted drug delivery |
| spellingShingle | Saravanan Alamelu Kamalesh Balakumar Venkatesan Kalist Shagirtha Manoj Kumar Srinivasan Chellasamy Panneerselvam Al Thabiani Aziz Mohammed Ali Alshehri Mohamed Ali Seyed Pugalendhi Pachaiappan Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery Drugs and Drug Candidates breast cancer inorganic nanoparticle malignancy nanoparticles organic nanoparticle targeted drug delivery |
| title | Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery |
| title_full | Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery |
| title_fullStr | Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery |
| title_full_unstemmed | Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery |
| title_short | Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery |
| title_sort | breast cancer treatment the potential of organic and inorganic nanocarriers in targeted drug delivery |
| topic | breast cancer inorganic nanoparticle malignancy nanoparticles organic nanoparticle targeted drug delivery |
| url | https://www.mdpi.com/2813-2998/3/4/46 |
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