Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer

Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer

Abstract Tumor metabolism often interferes with the immune microenvironment. Although natural killer (NK) cells play pivotal roles in antitumor immunity, the connection between NK cells and tumor metabolism remains unclear. Our systematic analysis of multiomics data and survival data from colorectal...

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Main Authors: Chen Wei, Kun Liao, Hao-Jie Chen, Zi-Xuan Xiao, Qi Meng, Ze-Kun Liu, Yun-Xin Lu, Hui Sheng, Hai-Yu Mo, Qi-Nian Wu, Yi Han, Zhao-Lei Zeng, Xin-Yuan Guan, Hui-Yan Luo, Huai-Qiang Ju, Rui-Hua Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02221-y
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https://doi.org/10.1038/s41392-025-02221-y

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