The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent

The dithiol mechanism of class I glutaredoxins promotes specificity for glutathione as a reducing agent

Class I glutaredoxins reversibly reduce glutathione- and nonglutathione disulfides with the help of reduced glutathione (GSH) using either a monothiol mechanism or a dithiol mechanism. The monothiol mechanism exclusively involves a single glutathionylated active-site cysteinyl residue, whereas the d...

Full description

Saved in:
Bibliographic Details
Main Authors: Lukas Lang, Philipp Reinert, Cedric Diaz, Marcel Deponte
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Redox Biology
Subjects:
Enzyme mechanism
Disulfide
Dithiol
Glutaredoxin
Glutathione
Redox catalysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724003884
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items