Recent advances in chirality sensing/recognition using supramolecular macrocycles

Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based...

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Bibliographic Details
Main Authors: Chunhong Liu, Leyong Wang, Zhouyu Wang, Wanhua Wu, Cheng Yang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Supramolecular Materials
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667240525000169
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Summary:Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis, drug development, and the advancement of functional materials. Supramolecular macrocycle-based chiral sensors offer unique advantages over traditional small-molecule chiral sensors. This review highlights recent advancements in chiral sensing using supramolecular macrocycles, categorizing them into two primary groups: achiral and chiral macrocycles, based on their configurational features. Furthermore, it systematically outlines the synthetic strategies for these macrocycles, emphasizing their applications in chiral recognition and sensing.
ISSN:2667-2405