Role of cyanotoxins in the development and promotion of cancer
Cyanotoxins are primarily produced by different species of cyanobacteria, also known as blue-green algae, and have appeared to be environmental poisons that have various toxic effects on animal health, including humans. Cyanotoxins have been linked to the development and promotion of multiple cancer...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750024001811 |
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| author | Siddharth Rajput Shruti Jain Debabrata Dash Nidhi Gupta Roshni Rajpoot Chandrama Prakash Upadhyaya Mohammed Latif Khan Raj Kumar Koiri |
| author_facet | Siddharth Rajput Shruti Jain Debabrata Dash Nidhi Gupta Roshni Rajpoot Chandrama Prakash Upadhyaya Mohammed Latif Khan Raj Kumar Koiri |
| author_sort | Siddharth Rajput |
| collection | DOAJ |
| description | Cyanotoxins are primarily produced by different species of cyanobacteria, also known as blue-green algae, and have appeared to be environmental poisons that have various toxic effects on animal health, including humans. Cyanotoxins have been linked to the development and promotion of multiple cancers in recent studies. Important cyanotoxins, such as microcystins, nodularins, and cylindrospermopsin, have been found to play significant roles in developing and promoting various cancers. These toxins are generally responsible for oxidative stress, DNA damage, and disrupt cellular signaling pathways thus the development of cancers in various cells. Cancer is a multistep process caused by multiple mutations in normal cells. Microcystin-LR inhibits protein phosphatases (PP1 and PP2A), which leads to abnormal cell proliferation and tumor development. Similar inhibition of PP1 and PP2A is shown by nodularin, and in fact, their mechanism of carcinogenesis is the same as that of microcystins to some extent. Cylindrospermopsin inhibits protein synthesis and thus has genotoxic effects and may promote the development of cancer. Anatoxin-a and saxitoxins are well-known neurotoxins but, are thought to have indirect carcinogenic effects based on the fact that they can induce oxidative stress and DNA damage in cells by producing reactive oxygen species, thus further studies are needed to fully elucidate their role in the development and promotion of cancer. This review provides a detailed account of how different cyanotoxins play a role in the development and promotion of cancer. |
| format | Article |
| id | doaj-art-df1e4c7c0ad34f1997bff37015b0922e |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-df1e4c7c0ad34f1997bff37015b0922e2024-12-19T10:54:50ZengElsevierToxicology Reports2214-75002024-12-0113101798Role of cyanotoxins in the development and promotion of cancerSiddharth Rajput0Shruti Jain1Debabrata Dash2Nidhi Gupta3Roshni Rajpoot4Chandrama Prakash Upadhyaya5Mohammed Latif Khan6Raj Kumar Koiri7Biochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaBiochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaBiochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaBiochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaBiochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaDepartment of Biotechnology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaDepartment of Botany, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, IndiaBiochemistry Laboratory, Department of Zoology, School of Biological Sciences, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, India; Correspondence to: Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya, Sagar, Madhya Pradesh 470003, India.Cyanotoxins are primarily produced by different species of cyanobacteria, also known as blue-green algae, and have appeared to be environmental poisons that have various toxic effects on animal health, including humans. Cyanotoxins have been linked to the development and promotion of multiple cancers in recent studies. Important cyanotoxins, such as microcystins, nodularins, and cylindrospermopsin, have been found to play significant roles in developing and promoting various cancers. These toxins are generally responsible for oxidative stress, DNA damage, and disrupt cellular signaling pathways thus the development of cancers in various cells. Cancer is a multistep process caused by multiple mutations in normal cells. Microcystin-LR inhibits protein phosphatases (PP1 and PP2A), which leads to abnormal cell proliferation and tumor development. Similar inhibition of PP1 and PP2A is shown by nodularin, and in fact, their mechanism of carcinogenesis is the same as that of microcystins to some extent. Cylindrospermopsin inhibits protein synthesis and thus has genotoxic effects and may promote the development of cancer. Anatoxin-a and saxitoxins are well-known neurotoxins but, are thought to have indirect carcinogenic effects based on the fact that they can induce oxidative stress and DNA damage in cells by producing reactive oxygen species, thus further studies are needed to fully elucidate their role in the development and promotion of cancer. This review provides a detailed account of how different cyanotoxins play a role in the development and promotion of cancer.http://www.sciencedirect.com/science/article/pii/S2214750024001811CyanotoxinsTumorCarcinogenesisNodularinMicrocystinCylindrospermopsin |
| spellingShingle | Siddharth Rajput Shruti Jain Debabrata Dash Nidhi Gupta Roshni Rajpoot Chandrama Prakash Upadhyaya Mohammed Latif Khan Raj Kumar Koiri Role of cyanotoxins in the development and promotion of cancer Toxicology Reports Cyanotoxins Tumor Carcinogenesis Nodularin Microcystin Cylindrospermopsin |
| title | Role of cyanotoxins in the development and promotion of cancer |
| title_full | Role of cyanotoxins in the development and promotion of cancer |
| title_fullStr | Role of cyanotoxins in the development and promotion of cancer |
| title_full_unstemmed | Role of cyanotoxins in the development and promotion of cancer |
| title_short | Role of cyanotoxins in the development and promotion of cancer |
| title_sort | role of cyanotoxins in the development and promotion of cancer |
| topic | Cyanotoxins Tumor Carcinogenesis Nodularin Microcystin Cylindrospermopsin |
| url | http://www.sciencedirect.com/science/article/pii/S2214750024001811 |
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