Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production
Based on the excellent radionuclide properties of 18F，amino acids labeled with radioactive nuclide 18F have shown its unique advantages in brain tumor imaging. A liquid target system with niobium as the target material and 18O(p，n)18F isotope was developed based on the 14 MeV cyclotron of the cyclot...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Board of Journal of Isotopes
2024-12-01
|
| Series: | Journal of Isotopes |
| Subjects: | |
| Online Access: | https://tws.xml-journal.net/article/doi/10.7538/tws.2023.youxian.100 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846098084648452096 |
|---|---|
| author | Fei WANG Li LING Guofang SONG Xianlu JIA Guang YANG Lijie ZHAO Peng HUANG Shigang HOU He ZHANG Pengfei ZHU Jie LIU |
| author_facet | Fei WANG Li LING Guofang SONG Xianlu JIA Guang YANG Lijie ZHAO Peng HUANG Shigang HOU He ZHANG Pengfei ZHU Jie LIU |
| author_sort | Fei WANG |
| collection | DOAJ |
| description | Based on the excellent radionuclide properties of 18F，amino acids labeled with radioactive nuclide 18F have shown its unique advantages in brain tumor imaging. A liquid target system with niobium as the target material and 18O(p，n)18F isotope was developed based on the 14 MeV cyclotron of the cyclotron research group of the Department of Nuclear Technology and Application，China Institute of Atomic Energy. In order to solve the problems of complicated structure and poor cooling effect of liquid target system cooled by helium，a liquid target system with direct water cooling is designed. The structure design process and material selection of liquid target are introduced in detail，and the stability of its transport system and control system is tested. The analysis results show that the liquid target system produced by this isotope has good stability. Under the irradiation of 20 μA beam intensity for 2 h，the yield of the product is 1.5 Ci. At present，it has been applied in Peking University，the system has good stability and repeatability，and has been highly praised by users. |
| format | Article |
| id | doaj-art-df0d91d324f943989b8aaca5e204f18b |
| institution | Kabale University |
| issn | 1000-7512 |
| language | zho |
| publishDate | 2024-12-01 |
| publisher | Editorial Board of Journal of Isotopes |
| record_format | Article |
| series | Journal of Isotopes |
| spelling | doaj-art-df0d91d324f943989b8aaca5e204f18b2025-01-02T02:07:43ZzhoEditorial Board of Journal of IsotopesJournal of Isotopes1000-75122024-12-0137658959710.7538/tws.2023.youxian.1002023-100Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F ProductionFei WANG0Li LING1Guofang SONG2Xianlu JIA3Guang YANG4Lijie ZHAO5Peng HUANG6Shigang HOU7He ZHANG8Pengfei ZHU9Jie LIU10China Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaChina Institute of Atomic Energy, Beijing 102413, ChinaBased on the excellent radionuclide properties of 18F，amino acids labeled with radioactive nuclide 18F have shown its unique advantages in brain tumor imaging. A liquid target system with niobium as the target material and 18O(p，n)18F isotope was developed based on the 14 MeV cyclotron of the cyclotron research group of the Department of Nuclear Technology and Application，China Institute of Atomic Energy. In order to solve the problems of complicated structure and poor cooling effect of liquid target system cooled by helium，a liquid target system with direct water cooling is designed. The structure design process and material selection of liquid target are introduced in detail，and the stability of its transport system and control system is tested. The analysis results show that the liquid target system produced by this isotope has good stability. Under the irradiation of 20 μA beam intensity for 2 h，the yield of the product is 1.5 Ci. At present，it has been applied in Peking University，the system has good stability and repeatability，and has been highly praised by users.https://tws.xml-journal.net/article/doi/10.7538/tws.2023.youxian.100liquid targetisotopecyclotron18f |
| spellingShingle | Fei WANG Li LING Guofang SONG Xianlu JIA Guang YANG Lijie ZHAO Peng HUANG Shigang HOU He ZHANG Pengfei ZHU Jie LIU Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production Journal of Isotopes liquid target isotope cyclotron 18f |
| title | Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production |
| title_full | Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production |
| title_fullStr | Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production |
| title_full_unstemmed | Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production |
| title_short | Development of Liquid Target System Based on 14 MeV Cyclotron Isotope 18F Production |
| title_sort | development of liquid target system based on 14 mev cyclotron isotope 18f production |
| topic | liquid target isotope cyclotron 18f |
| url | https://tws.xml-journal.net/article/doi/10.7538/tws.2023.youxian.100 |
| work_keys_str_mv | AT feiwang developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT liling developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT guofangsong developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT xianlujia developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT guangyang developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT lijiezhao developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT penghuang developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT shiganghou developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT hezhang developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT pengfeizhu developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction AT jieliu developmentofliquidtargetsystembasedon14mevcyclotronisotope18fproduction |