The biological and functional restoration of spinal cord injury
Spinal cord injury (SCI) is a severe central nervous system disease. Serious complications can occur as a result of loss of sensory and motor functions below the injury level and a consistent hostile response in the injury region. The quality of life is decreased and the prognosis is poor. Therefore...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2024-12-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2960 |
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| author | JIAN Feng‐zeng YANG Qi‐qi DUAN Wan‐ru |
| author_facet | JIAN Feng‐zeng YANG Qi‐qi DUAN Wan‐ru |
| author_sort | JIAN Feng‐zeng |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is a severe central nervous system disease. Serious complications can occur as a result of loss of sensory and motor functions below the injury level and a consistent hostile response in the injury region. The quality of life is decreased and the prognosis is poor. Therefore, a functional restoration is essential for better outcomes. Restoration of the anatomical structure and microenvironment of the damaged region can be obtained by molecular drug modulation, neuroprotection, neuroregeneration, stem cell therapy, and biomaterial‐based tissue engineering. Functional restoration can be achieved by boosting neuroplasticity with activity‐based therapy or electrical stimulation, or by implanting interfaces that allowed accessibility to interactive devices. Combined therapy showed potentially better outcomes. |
| format | Article |
| id | doaj-art-df079cfdfc1b41d9bff93fe8902de9fb |
| institution | Kabale University |
| issn | 1672-6731 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj-art-df079cfdfc1b41d9bff93fe8902de9fb2025-01-14T12:36:56ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312024-12-01241297798010.3969/j.issn.1672‐6731.2024.12.001The biological and functional restoration of spinal cord injuryJIAN Feng‐zeng0YANG Qi‐qi1DUAN Wan‐ru2Department of Neurosurgery, Xuanwu Hospital, Capital Medical University; Lab of Spinal Cord Injury and Functional Reconstruction, Neurospine Center, China International Neuroscience Institute (CHINA ⁃ INI), Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University; Lab of Spinal Cord Injury and Functional Reconstruction, Neurospine Center, China International Neuroscience Institute (CHINA ⁃ INI), Beijing 100053, ChinaDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University; Lab of Spinal Cord Injury and Functional Reconstruction, Neurospine Center, China International Neuroscience Institute (CHINA ⁃ INI), Beijing 100053, ChinaSpinal cord injury (SCI) is a severe central nervous system disease. Serious complications can occur as a result of loss of sensory and motor functions below the injury level and a consistent hostile response in the injury region. The quality of life is decreased and the prognosis is poor. Therefore, a functional restoration is essential for better outcomes. Restoration of the anatomical structure and microenvironment of the damaged region can be obtained by molecular drug modulation, neuroprotection, neuroregeneration, stem cell therapy, and biomaterial‐based tissue engineering. Functional restoration can be achieved by boosting neuroplasticity with activity‐based therapy or electrical stimulation, or by implanting interfaces that allowed accessibility to interactive devices. Combined therapy showed potentially better outcomes.http://www.cjcnn.org/index.php/cjcnn/article/view/2960spinal cord injuriesneuronal plasticityneural networks，computerreview |
| spellingShingle | JIAN Feng‐zeng YANG Qi‐qi DUAN Wan‐ru The biological and functional restoration of spinal cord injury Chinese Journal of Contemporary Neurology and Neurosurgery spinal cord injuries neuronal plasticity neural networks，computer review |
| title | The biological and functional restoration of spinal cord injury |
| title_full | The biological and functional restoration of spinal cord injury |
| title_fullStr | The biological and functional restoration of spinal cord injury |
| title_full_unstemmed | The biological and functional restoration of spinal cord injury |
| title_short | The biological and functional restoration of spinal cord injury |
| title_sort | biological and functional restoration of spinal cord injury |
| topic | spinal cord injuries neuronal plasticity neural networks，computer review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2960 |
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