The Impact of Periodontal Therapy on Systemic Inflammatory Markers and Cardiovascular Disease Risk in Patients with Chronic Periodontitis
Background: A common inflammatory condition that damages the tissues that support teeth, chronic periodontitis has become more closely associated with systemic health conditions, especially cardiovascular disease (CVD). Materials and Methods: In this randomized controlled experiment, 100 individuals...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1216_24 |
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| Summary: | Background:
A common inflammatory condition that damages the tissues that support teeth, chronic periodontitis has become more closely associated with systemic health conditions, especially cardiovascular disease (CVD).
Materials and Methods:
In this randomized controlled experiment, 100 individuals with a diagnosis of chronic periodontitis were included. Two groups of participants were created: a treatment group (n = 50) that received scaling and root planning as well as other non-surgical periodontal care, and a control group (n = 50) that did not receive any treatment. Measurements were taken at baseline and 6 months after therapy for systemic inflammatory markers, including as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). The Framingham Risk Score (FRS) was used at the same intervals to evaluate the risk of CVD.
Results:
At 6 months after therapy, patients in the treatment group had substantial reductions in all measured inflammatory markers: CRP was down 30% (P < 0.01), IL-6 was down 25% (P < 0.05), and TNF-α was down 28% (P < 0.01). In the therapy group, the Framingham Risk Score dropped by 15% (P < 0.05), suggesting a lower chance of cardiovascular disease. There were no noteworthy alterations noted in the group under control.
Conclusion:
In individuals with persistent periodontitis, non-surgical periodontal treatment may minimize the risk of cardiovascular disease and considerably reduce systemic inflammatory indicators. |
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| ISSN: | 0976-4879 0975-7406 |