Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances
Abstract Pseudomonas aeruginosa is a significant opportunistic pathogen, and its complex mechanisms of antibiotic resistance pose a challenge to modern medicine. This literature review explores the advancements made from 1979 to 2024 in understanding the regulatory networks of antibiotic resistance...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-11-01
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| Series: | Molecular Biomedicine |
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| Online Access: | https://doi.org/10.1186/s43556-024-00221-y |
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| _version_ | 1846148139595071488 |
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| author | Yuanjing Zhao Haoran Xu Hui Wang Ping Wang Simin Chen |
| author_facet | Yuanjing Zhao Haoran Xu Hui Wang Ping Wang Simin Chen |
| author_sort | Yuanjing Zhao |
| collection | DOAJ |
| description | Abstract Pseudomonas aeruginosa is a significant opportunistic pathogen, and its complex mechanisms of antibiotic resistance pose a challenge to modern medicine. This literature review explores the advancements made from 1979 to 2024 in understanding the regulatory networks of antibiotic resistance genes in Pseudomonas aeruginosa, with a particular focus on the molecular underpinnings of these resistance mechanisms. The review highlights four main pathways involved in drug resistance: reducing outer membrane permeability, enhancing active efflux systems, producing antibiotic-inactivating enzymes, and forming biofilms. These pathways are intricately regulated by a combination of genetic regulation, transcriptional regulators, two-component signal transduction, DNA methylation, and small RNA molecules. Through an in-depth analysis and synthesis of existing literature, we identify key regulatory elements mexT, ampR, and argR as potential targets for novel antimicrobial strategies. A profound understanding of the core control nodes of drug resistance offers a new perspective for therapeutic intervention, suggesting that modulating these elements could potentially reverse resistance and restore bacterial susceptibility to antibiotics. The review looks forward to future research directions, proposing the use of gene editing and systems biology to further understand resistance mechanisms and to develop effective antimicrobial strategies against Pseudomonas aeruginosa. This review is expected to provide innovative solutions to the problem of drug resistance in infectious diseases. |
| format | Article |
| id | doaj-art-def536d7ddb14ae9bec5b49e459e47f0 |
| institution | Kabale University |
| issn | 2662-8651 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Molecular Biomedicine |
| spelling | doaj-art-def536d7ddb14ae9bec5b49e459e47f02024-12-01T12:06:09ZengSpringerMolecular Biomedicine2662-86512024-11-015112610.1186/s43556-024-00221-yMultidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advancesYuanjing Zhao0Haoran Xu1Hui Wang2Ping Wang3Simin Chen4State Key Laboratory of South Western Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese MedicineState Key Laboratory of South Western Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese MedicineState Key Laboratory of South Western Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese MedicineState Key Laboratory of South Western Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese MedicineState Key Laboratory of South Western Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese MedicineAbstract Pseudomonas aeruginosa is a significant opportunistic pathogen, and its complex mechanisms of antibiotic resistance pose a challenge to modern medicine. This literature review explores the advancements made from 1979 to 2024 in understanding the regulatory networks of antibiotic resistance genes in Pseudomonas aeruginosa, with a particular focus on the molecular underpinnings of these resistance mechanisms. The review highlights four main pathways involved in drug resistance: reducing outer membrane permeability, enhancing active efflux systems, producing antibiotic-inactivating enzymes, and forming biofilms. These pathways are intricately regulated by a combination of genetic regulation, transcriptional regulators, two-component signal transduction, DNA methylation, and small RNA molecules. Through an in-depth analysis and synthesis of existing literature, we identify key regulatory elements mexT, ampR, and argR as potential targets for novel antimicrobial strategies. A profound understanding of the core control nodes of drug resistance offers a new perspective for therapeutic intervention, suggesting that modulating these elements could potentially reverse resistance and restore bacterial susceptibility to antibiotics. The review looks forward to future research directions, proposing the use of gene editing and systems biology to further understand resistance mechanisms and to develop effective antimicrobial strategies against Pseudomonas aeruginosa. This review is expected to provide innovative solutions to the problem of drug resistance in infectious diseases.https://doi.org/10.1186/s43556-024-00221-yDrug resistance pathwaysGene regulatory networkRegulatory factorsPseudomonas aeruginosa |
| spellingShingle | Yuanjing Zhao Haoran Xu Hui Wang Ping Wang Simin Chen Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances Molecular Biomedicine Drug resistance pathways Gene regulatory network Regulatory factors Pseudomonas aeruginosa |
| title | Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances |
| title_full | Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances |
| title_fullStr | Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances |
| title_full_unstemmed | Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances |
| title_short | Multidrug resistance in Pseudomonas aeruginosa: genetic control mechanisms and therapeutic advances |
| title_sort | multidrug resistance in pseudomonas aeruginosa genetic control mechanisms and therapeutic advances |
| topic | Drug resistance pathways Gene regulatory network Regulatory factors Pseudomonas aeruginosa |
| url | https://doi.org/10.1186/s43556-024-00221-y |
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