T-piece versus pressure-support ventilation for spontaneous breathing trials before extubation in patients at high risk of reintubation: protocol for a multicentre, randomised controlled trial (TIP-EX)

T-piece versus pressure-support ventilation for spontaneous breathing trials before extubation in patients at high risk of reintubation: protocol for a multicentre, randomised controlled trial (TIP-EX)

Introduction In intensive care unit (ICU), the decision of extubation is a critical time because mortality is particularly high in case of reintubation. To reduce that risk, guidelines recommend to systematically perform a spontaneous breathing trial (SBT) before extubation in order to mimic the pos...

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Main Authors: Christophe Guitton, Rémi Coudroy, Jean-Pierre Frat, Stephan Ehrmann, Nicolas Terzi, Gwenaël Prat, Damien Contou, Jeremy Bourenne, Arnaud Gacouin, Jean Dellamonica, Jean-Pierre Quenot, Jérôme Devaquet, Emmanuel Vivier, Stéphanie Ragot, Arnaud W Thille, Mai-Anh Nay, Laurence Dangers, Antoine Romen, Guillaume Lacave, Béatrice Lacombe, Jean Reignier, Gaetan Beduneau, Anahita Rouze, Agathe Delbove, Nicholas Sedillot, Jean-Paul Mira, Alexandre Lautrette, Laurent Argaud, Quentin Levrat, Marie-Ange Azais, Christophe Leroy, Martin Dres, René Robert
Format: Article
Language:English
Published: BMJ Publishing Group 2020-11-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/11/e042619.full
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