Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial
Objective: To evaluate the efficacy of adjuvant therapy with Concentrated Growth Factor (CGF) along with xenograft and autograft in mandible fractures, in terms of bone density gain and healing over the period of 6 months. Methodology: This was a Randomized Clinical Trial conducted at a public se...
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| Language: | English |
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University of Lahore
2024-12-01
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| Series: | Journal of University College of Medicine and Dentistry |
| Online Access: | https://journals.uol.edu.pk/jucmd/article/view/3519 |
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| author | Samreen Malik Abdul Hafeez Shaikh Tahera Ayub Amna Rehman Hijab Farid Khan Arifa Haque |
| author_facet | Samreen Malik Abdul Hafeez Shaikh Tahera Ayub Amna Rehman Hijab Farid Khan Arifa Haque |
| author_sort | Samreen Malik |
| collection | DOAJ |
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Objective: To evaluate the efficacy of adjuvant therapy with Concentrated Growth Factor (CGF) along with xenograft and autograft in mandible fractures, in terms of bone density gain and healing over the period of 6 months.
Methodology: This was a Randomized Clinical Trial conducted at a public sector tertiary care hospital in Karachi from May 2019 to July 2022. It included patients with mandible fractures requiring bone grafts due to non-union, delayed union, or mal-union. The patients were divided into three groups, each consisting of 20 patients. Group A underwent mandibular surgery using autograft alone, Group B received autograft combined with CGF, and Group C received xenograft combined with CGF. The participants were monitored using serial cone-beam computed tomography at the 4th and 6th months post-operatively to evaluate bone healing and bone density. By the end of the study, all cone-beam CT scans were evaluated for bone density.
Results: The results showed a significant increase in bone bulk formation across all three groups between the 4th and 6th month, highlighting the effectiveness of all treatment modalities (p < 0.001). However, intergroup comparison revealed that bone density was comparatively higher in groups B and C, where CGF was used as an adjuvant, than in group A. However, the mean difference in bone density over the 6 months period was similar for Group A (-229.2) and Group B (-227.7), while Group C showed a slightly greater mean difference of -237.9
Conclusion: CGF is equally effective with both autograft and xenograft. However, using CGF with xenograft is preferable, as it helps avoid donor site morbidity and reduces patient inconvenience associated with autograft harvesting.
Key words: Autograft, Concentrated Growth Factor, Xenograft, Cone Beam Computed Tomography, Mandible
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| format | Article |
| id | doaj-art-deac86b23d1f4b9c9d26adb81b6ee414 |
| institution | Kabale University |
| issn | 2790-3443 2790-3451 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Lahore |
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| series | Journal of University College of Medicine and Dentistry |
| spelling | doaj-art-deac86b23d1f4b9c9d26adb81b6ee4142024-12-26T21:10:33ZengUniversity of LahoreJournal of University College of Medicine and Dentistry2790-34432790-34512024-12-014110.51846/jucmd.v4i1.3519Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical TrialSamreen Malik0Abdul Hafeez Shaikh1Tahera Ayub2Amna Rehman3Hijab Farid Khan4Arifa Haque5Department of Oral Medicine, Liaquat College of Medicine and Dentistry, Karachi, Pakistan.Associate Professor, Department of Oral and Maxillofacial Surgery, Dow International Dental College, Karachi. Pakistan.Department of Oral and Maxillofacial Surgery, Liaquat College of Medicine and Dentistry, Karachi, Pakistan.Assistant Professor, Department of Oral and Maxillofacial Surgery, Liaquat College of Medicine and Dentistry, Karachi, Pakistan.Assistant Professor, Department of Oral Medicine, Liaquat College of Medicine and Dentistry, Karachi, Pakistan.Assistant Professor, Department of Oral Pathology, Liaquat College of Medicine and Dentistry, Karachi, Pakistan. Objective: To evaluate the efficacy of adjuvant therapy with Concentrated Growth Factor (CGF) along with xenograft and autograft in mandible fractures, in terms of bone density gain and healing over the period of 6 months. Methodology: This was a Randomized Clinical Trial conducted at a public sector tertiary care hospital in Karachi from May 2019 to July 2022. It included patients with mandible fractures requiring bone grafts due to non-union, delayed union, or mal-union. The patients were divided into three groups, each consisting of 20 patients. Group A underwent mandibular surgery using autograft alone, Group B received autograft combined with CGF, and Group C received xenograft combined with CGF. The participants were monitored using serial cone-beam computed tomography at the 4th and 6th months post-operatively to evaluate bone healing and bone density. By the end of the study, all cone-beam CT scans were evaluated for bone density. Results: The results showed a significant increase in bone bulk formation across all three groups between the 4th and 6th month, highlighting the effectiveness of all treatment modalities (p < 0.001). However, intergroup comparison revealed that bone density was comparatively higher in groups B and C, where CGF was used as an adjuvant, than in group A. However, the mean difference in bone density over the 6 months period was similar for Group A (-229.2) and Group B (-227.7), while Group C showed a slightly greater mean difference of -237.9 Conclusion: CGF is equally effective with both autograft and xenograft. However, using CGF with xenograft is preferable, as it helps avoid donor site morbidity and reduces patient inconvenience associated with autograft harvesting. Key words: Autograft, Concentrated Growth Factor, Xenograft, Cone Beam Computed Tomography, Mandible https://journals.uol.edu.pk/jucmd/article/view/3519 |
| spellingShingle | Samreen Malik Abdul Hafeez Shaikh Tahera Ayub Amna Rehman Hijab Farid Khan Arifa Haque Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial Journal of University College of Medicine and Dentistry |
| title | Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial |
| title_full | Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial |
| title_fullStr | Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial |
| title_full_unstemmed | Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial |
| title_short | Efficacy of Concentrated Growth Factor with Autograft and Xenograft in Mandible Fractures: A Randomized Clinical Trial |
| title_sort | efficacy of concentrated growth factor with autograft and xenograft in mandible fractures a randomized clinical trial |
| url | https://journals.uol.edu.pk/jucmd/article/view/3519 |
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