The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease.
<h4>Objectives</h4>1) To deduce T2, the inverse of the transverse relaxation rate (R2), in the hippocampus of healthy adults; 2) to investigate the brain iron deposition in Alzheimer's disease (AD) patients and age-matched healthy controls using T2-values.<h4>Methods</h4>...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0076203 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849330908751986688 |
|---|---|
| author | Zhuren Luo Xiongjie Zhuang Dushyant Kumar Xiurong Wu Cen Yue Chengkun Han Jiancheng Lv |
| author_facet | Zhuren Luo Xiongjie Zhuang Dushyant Kumar Xiurong Wu Cen Yue Chengkun Han Jiancheng Lv |
| author_sort | Zhuren Luo |
| collection | DOAJ |
| description | <h4>Objectives</h4>1) To deduce T2, the inverse of the transverse relaxation rate (R2), in the hippocampus of healthy adults; 2) to investigate the brain iron deposition in Alzheimer's disease (AD) patients and age-matched healthy controls using T2-values.<h4>Methods</h4>T2-weighted data from the bilateral-hippocampi of ten AD patients and sixty healthy controls were collected at six echo time points using multi-slice multi-echo turbo spin echo (MSME-TSE) imaging on a 3.0 T MR-scanner, followed by the neuropsychological testing. The correlations between T2-values and Mini-Mental State Examination (MMSE) scores were investigated on group-wise basis (covariates in the group-wise analyses: gender, age, side and healthy/AD).<h4>Results</h4>There were no significant differences in hippocampal T2-values on intra-gender and inter-gender basis (P > 0.05). Hippocampal T2-values of both sides were similar (right: 85.2±2.4 milliseconds; left: 85.3±2.5 milliseconds). The bilateral hippocampal T2 values correlated moderately with age (right: r = -0.59; left: -0.58; P < 0.001). The AD-group had significantly lower T2-values in the hippocampus when compared to normal controls (P < 0.001) and such low T2-values had a strong positive correlation with the MMSE score (R (2) = 0.97; P < 0.05).<h4>Conclusion</h4>Patients with AD showed significantly lower T2 values, which can be attributed to the increased iron depositions in the hippocampus. A positive correlation between T2-values and cognition scores suggests that quantitative T2 can be used in the early diagnosis of AD and in the monitoring of the treatment response. |
| format | Article |
| id | doaj-art-de9087e7d0ca46e7ac9f5d7789331d94 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-de9087e7d0ca46e7ac9f5d7789331d942025-08-20T03:46:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7620310.1371/journal.pone.0076203The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease.Zhuren LuoXiongjie ZhuangDushyant KumarXiurong WuCen YueChengkun HanJiancheng Lv<h4>Objectives</h4>1) To deduce T2, the inverse of the transverse relaxation rate (R2), in the hippocampus of healthy adults; 2) to investigate the brain iron deposition in Alzheimer's disease (AD) patients and age-matched healthy controls using T2-values.<h4>Methods</h4>T2-weighted data from the bilateral-hippocampi of ten AD patients and sixty healthy controls were collected at six echo time points using multi-slice multi-echo turbo spin echo (MSME-TSE) imaging on a 3.0 T MR-scanner, followed by the neuropsychological testing. The correlations between T2-values and Mini-Mental State Examination (MMSE) scores were investigated on group-wise basis (covariates in the group-wise analyses: gender, age, side and healthy/AD).<h4>Results</h4>There were no significant differences in hippocampal T2-values on intra-gender and inter-gender basis (P > 0.05). Hippocampal T2-values of both sides were similar (right: 85.2±2.4 milliseconds; left: 85.3±2.5 milliseconds). The bilateral hippocampal T2 values correlated moderately with age (right: r = -0.59; left: -0.58; P < 0.001). The AD-group had significantly lower T2-values in the hippocampus when compared to normal controls (P < 0.001) and such low T2-values had a strong positive correlation with the MMSE score (R (2) = 0.97; P < 0.05).<h4>Conclusion</h4>Patients with AD showed significantly lower T2 values, which can be attributed to the increased iron depositions in the hippocampus. A positive correlation between T2-values and cognition scores suggests that quantitative T2 can be used in the early diagnosis of AD and in the monitoring of the treatment response.https://doi.org/10.1371/journal.pone.0076203 |
| spellingShingle | Zhuren Luo Xiongjie Zhuang Dushyant Kumar Xiurong Wu Cen Yue Chengkun Han Jiancheng Lv The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease. PLoS ONE |
| title | The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease. |
| title_full | The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease. |
| title_fullStr | The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease. |
| title_full_unstemmed | The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease. |
| title_short | The correlation of hippocampal T2-mapping with neuropsychology test in patients with Alzheimer's disease. |
| title_sort | correlation of hippocampal t2 mapping with neuropsychology test in patients with alzheimer s disease |
| url | https://doi.org/10.1371/journal.pone.0076203 |
| work_keys_str_mv | AT zhurenluo thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT xiongjiezhuang thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT dushyantkumar thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT xiurongwu thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT cenyue thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT chengkunhan thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT jianchenglv thecorrelationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT zhurenluo correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT xiongjiezhuang correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT dushyantkumar correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT xiurongwu correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT cenyue correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT chengkunhan correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease AT jianchenglv correlationofhippocampalt2mappingwithneuropsychologytestinpatientswithalzheimersdisease |