Nitazoxanide controls virus viability through its impact on membrane bioenergetics

Nitazoxanide controls virus viability through its impact on membrane bioenergetics

Abstract Viruses are dependent on cellular energy metabolism for their replication, and the drug nitazoxanide (Alinia) was shown to interfere with both processes. Nitazoxanide is an uncoupler of mitochondrial oxidative phosphorylation (OXPHOS). Our hypothesis was that mitochondrial uncoupling underl...

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Bibliographic Details
Main Authors: Noureddine Hammad, Céline Ransy, Benoit Pinson, Jeremy Talmasson, Christian Bréchot, Jean-François Rossignol, Frédéric Bouillaud
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Mitochondria
Mitochondrial uncoupling
Cellular bioenergetics
Glucose metabolism
Antiviral
ATP use
Online Access:https://doi.org/10.1038/s41598-024-78694-8
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https://doi.org/10.1038/s41598-024-78694-8

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