Depression among keratoconus patients: a systematic review and meta-analysis
BackgroundKeratoconus (KC) is a chronic corneal disease that typically presents in early adulthood, and may potentially result in poor mental health in affected individuals. The evidence regarding the association of depression with KC is controversial. Hence, we investigated the association between...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1477411/full |
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| author | Reza Moshfeghinia Reza Moshfeghinia Reza Moshfeghinia Ali Arman Ali Arman Navid Sobhi Golnoush Mahmoudinezhad Hossein Molavi Vardanjani |
| author_facet | Reza Moshfeghinia Reza Moshfeghinia Reza Moshfeghinia Ali Arman Ali Arman Navid Sobhi Golnoush Mahmoudinezhad Hossein Molavi Vardanjani |
| author_sort | Reza Moshfeghinia |
| collection | DOAJ |
| description | BackgroundKeratoconus (KC) is a chronic corneal disease that typically presents in early adulthood, and may potentially result in poor mental health in affected individuals. The evidence regarding the association of depression with KC is controversial. Hence, we investigated the association between depression and KC via a systematic review and meta-analysis.MethodsFive electronic medical databases (PubMed, Scopus, PsycINFO, Web of Science, and CINAHL Complete) were systematically queried for English-language records from their inception to January 8, 2024. We include observational studies that measured the risk of depression or compared depression scores in KC patients in comparison to healthy ones. The Newcastle–Ottawa Quality Assessment Scale was utilized to assess bias risk in the included studies. Random-effect modeling was applied for meta-analysis (STATA-17).ResultsOut of the 159 documents retrieved, seven articles were deemed relevant after screening. An analysis involving 83 KC patients and 3,186 controls indicated that KC participants had significantly higher depression scores [SMD: 0.71 [0.31, 1.11]; p < 0.01, I2: 52.7%]. However, a meta-analysis of four studies comparing depression rates in KC patients (n = 23,838) to control groups (n = 73,482) found no increased risk of depression among KC patients compared to controls [OR: 1.13 [0.66, 1.94]; p = 0.65, I2: 95.35%].ConclusionWhile KC patients exhibit significantly higher depression scores compared to controls, a meta-analysis indicates no increased overall risk of depression among KC patients. These findings highlight the complexity of the relationship between keratoconus and mental health, warranting further investigation.Systematic review registrationPROSPERO, identifier, CRD42024502247, available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024502247. |
| format | Article |
| id | doaj-art-de67e15b90db4de2bf9e2f711a218b38 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-de67e15b90db4de2bf9e2f711a218b382024-11-22T05:10:21ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-11-011210.3389/fpubh.2024.14774111477411Depression among keratoconus patients: a systematic review and meta-analysisReza Moshfeghinia0Reza Moshfeghinia1Reza Moshfeghinia2Ali Arman3Ali Arman4Navid Sobhi5Golnoush Mahmoudinezhad6Hossein Molavi Vardanjani7Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IranMD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranResearch Center for Psychiatry and Behavioral Sciences, Shiraz University of Medical Sciences, Shiraz, IranStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, IranMD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranNikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Ophthalmology at the Shiley Eye Institute, University of California at San Diego, La Jolla, CA, United StatesMD-MPH Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranBackgroundKeratoconus (KC) is a chronic corneal disease that typically presents in early adulthood, and may potentially result in poor mental health in affected individuals. The evidence regarding the association of depression with KC is controversial. Hence, we investigated the association between depression and KC via a systematic review and meta-analysis.MethodsFive electronic medical databases (PubMed, Scopus, PsycINFO, Web of Science, and CINAHL Complete) were systematically queried for English-language records from their inception to January 8, 2024. We include observational studies that measured the risk of depression or compared depression scores in KC patients in comparison to healthy ones. The Newcastle–Ottawa Quality Assessment Scale was utilized to assess bias risk in the included studies. Random-effect modeling was applied for meta-analysis (STATA-17).ResultsOut of the 159 documents retrieved, seven articles were deemed relevant after screening. An analysis involving 83 KC patients and 3,186 controls indicated that KC participants had significantly higher depression scores [SMD: 0.71 [0.31, 1.11]; p < 0.01, I2: 52.7%]. However, a meta-analysis of four studies comparing depression rates in KC patients (n = 23,838) to control groups (n = 73,482) found no increased risk of depression among KC patients compared to controls [OR: 1.13 [0.66, 1.94]; p = 0.65, I2: 95.35%].ConclusionWhile KC patients exhibit significantly higher depression scores compared to controls, a meta-analysis indicates no increased overall risk of depression among KC patients. These findings highlight the complexity of the relationship between keratoconus and mental health, warranting further investigation.Systematic review registrationPROSPERO, identifier, CRD42024502247, available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024502247.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1477411/fullkeratoconusdepressionmental healthsystematic reviewmeta-analysis |
| spellingShingle | Reza Moshfeghinia Reza Moshfeghinia Reza Moshfeghinia Ali Arman Ali Arman Navid Sobhi Golnoush Mahmoudinezhad Hossein Molavi Vardanjani Depression among keratoconus patients: a systematic review and meta-analysis Frontiers in Public Health keratoconus depression mental health systematic review meta-analysis |
| title | Depression among keratoconus patients: a systematic review and meta-analysis |
| title_full | Depression among keratoconus patients: a systematic review and meta-analysis |
| title_fullStr | Depression among keratoconus patients: a systematic review and meta-analysis |
| title_full_unstemmed | Depression among keratoconus patients: a systematic review and meta-analysis |
| title_short | Depression among keratoconus patients: a systematic review and meta-analysis |
| title_sort | depression among keratoconus patients a systematic review and meta analysis |
| topic | keratoconus depression mental health systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1477411/full |
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