Bridging the gap: From petri dish to patient - Advancements in translational drug discovery
Translational research serves as the bridge between basic research and practical applications in clinical settings. The journey from ''bench to bedside'' is fraught with challenges and complexities such as the often-observed disparity between how compounds behave in a laboratory...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024173483 |
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| author | Mohamed El-Tanani Syed Arman Rabbani Yahia El-Tanani Ismail I. Matalka Ikramy A. Khalil |
| author_facet | Mohamed El-Tanani Syed Arman Rabbani Yahia El-Tanani Ismail I. Matalka Ikramy A. Khalil |
| author_sort | Mohamed El-Tanani |
| collection | DOAJ |
| description | Translational research serves as the bridge between basic research and practical applications in clinical settings. The journey from ''bench to bedside'' is fraught with challenges and complexities such as the often-observed disparity between how compounds behave in a laboratory setting versus in the complex systems of living organisms. The challenge is further compounded by the limited ability of in vitro models to mimic the specific biochemical environment of human tissues. This article explores and details the recent advancements and innovative approaches that are increasingly successful in bridging the gap between laboratory research and patient care. These advancements include, but are not limited to, sophisticated in vitro models such as organ-on-a-chip and computational models that utilize artificial intelligence to predict drug efficacy and safety. The article aims to showcase how these technologies improve the predictability of drug performance in human bodies and significantly speed up the drug development process. Furthermore, it discusses the role of biomarker discovery in preparation of more targeted and personalized therapy approaches and covers the impact of regulatory changes designed to facilitate drug approvals. Additionally, by providing detailed case studies of successful applications, we illustrate the practical impacts of these innovations on drug discovery and patient care. |
| format | Article |
| id | doaj-art-de65f28dd3f8476eb1a840a2d56fa531 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-de65f28dd3f8476eb1a840a2d56fa5312025-01-17T04:50:53ZengElsevierHeliyon2405-84402025-01-01111e41317Bridging the gap: From petri dish to patient - Advancements in translational drug discoveryMohamed El-Tanani0Syed Arman Rabbani1Yahia El-Tanani2Ismail I. Matalka3Ikramy A. Khalil4College of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates; Corresponding author. RAK College of Pharmacy, RAK Medical & Health Sciences University, P.O. Box 11172, Ras Al Khaimah, United Arab Emirates.College of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab EmiratesRoyal Cornwall Hospital Trust, NHS, United KingdomRas Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates; Department of Pathology and Microbiology, Medicine, Jordan University of Science and Technology, Irbid, JordanCollege of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates; Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt; Corresponding author. College of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates.Translational research serves as the bridge between basic research and practical applications in clinical settings. The journey from ''bench to bedside'' is fraught with challenges and complexities such as the often-observed disparity between how compounds behave in a laboratory setting versus in the complex systems of living organisms. The challenge is further compounded by the limited ability of in vitro models to mimic the specific biochemical environment of human tissues. This article explores and details the recent advancements and innovative approaches that are increasingly successful in bridging the gap between laboratory research and patient care. These advancements include, but are not limited to, sophisticated in vitro models such as organ-on-a-chip and computational models that utilize artificial intelligence to predict drug efficacy and safety. The article aims to showcase how these technologies improve the predictability of drug performance in human bodies and significantly speed up the drug development process. Furthermore, it discusses the role of biomarker discovery in preparation of more targeted and personalized therapy approaches and covers the impact of regulatory changes designed to facilitate drug approvals. Additionally, by providing detailed case studies of successful applications, we illustrate the practical impacts of these innovations on drug discovery and patient care.http://www.sciencedirect.com/science/article/pii/S2405844024173483Translational researchDrug discoverypatient careIn vitro modelsIn vivo models |
| spellingShingle | Mohamed El-Tanani Syed Arman Rabbani Yahia El-Tanani Ismail I. Matalka Ikramy A. Khalil Bridging the gap: From petri dish to patient - Advancements in translational drug discovery Heliyon Translational research Drug discovery patient care In vitro models In vivo models |
| title | Bridging the gap: From petri dish to patient - Advancements in translational drug discovery |
| title_full | Bridging the gap: From petri dish to patient - Advancements in translational drug discovery |
| title_fullStr | Bridging the gap: From petri dish to patient - Advancements in translational drug discovery |
| title_full_unstemmed | Bridging the gap: From petri dish to patient - Advancements in translational drug discovery |
| title_short | Bridging the gap: From petri dish to patient - Advancements in translational drug discovery |
| title_sort | bridging the gap from petri dish to patient advancements in translational drug discovery |
| topic | Translational research Drug discovery patient care In vitro models In vivo models |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024173483 |
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