Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis
Background: Statins are the cornerstone of low-density lipoprotein cholesterol (LDL-C)-lowering therapy; however, the therapeutic efficacy of statins in countering atherosclerotic cardiovascular disease (ASCVD) is compromised by the concurrent elevation of proprotein convertase subtilisin/kexin type...
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Main Authors: | Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-12-01
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Series: | Journal of Sport and Health Science |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2095254624001650 |
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