The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat
BackgroundThe effects of camel milk in inflammation and systemic oxidative stress of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) associated with small airway inflammation in rats were investigated.Methods35 male Wistar rats were randomly divided into five groups: (a) co...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2024.1464432/full |
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| author | Sepide Behrouz Sepide Behrouz Mahla Mohammadi Hadi Sarir Mohammad Hossein Boskabady Mohammad Hossein Boskabady |
| author_facet | Sepide Behrouz Sepide Behrouz Mahla Mohammadi Hadi Sarir Mohammad Hossein Boskabady Mohammad Hossein Boskabady |
| author_sort | Sepide Behrouz |
| collection | DOAJ |
| description | BackgroundThe effects of camel milk in inflammation and systemic oxidative stress of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) associated with small airway inflammation in rats were investigated.Methods35 male Wistar rats were randomly divided into five groups: (a) control, (b) CS-exposed rats, c and (d) CS-exposed rats treated with the 4 and 8 mL/kg camel milk, and (e) CS-exposed rats treated with 1 mg/kg dexamethasone.ResultsTotal and differential WBC counts, serum level of TNF-α and malondialdehyde (MDA) level in serum and homogenized tissues of the heart, kidney, liver, and testicle were significantly increased, but catalase (CAT), superoxide dismutase (SOD) and thiol levels were significantly decreased in CS-exposed rats (p < 0.01 to p < 0.001). Treatment with dexamethasone and both doses of camel milk improved all measured variables compared to the COPD group (p < 0.05 to p < 0.001). The improvements of most variables in the treated group with high dose of camel milk were higher than the effect of dexamethasone (p < 0.05 to p < 0.001). These findings suggest that camel milk has a therapeutic potential for treating systemic oxidative stress and inflammatory induced by CS.ConclusionTherefore, camel milk might be effective in attenuating the effects of CS-induced systemic inflammation and oxidative stress. |
| format | Article |
| id | doaj-art-de3b42bf66c64eb6b0b0fea64e350bb5 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Veterinary Science |
| spelling | doaj-art-de3b42bf66c64eb6b0b0fea64e350bb52024-12-13T16:34:14ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692024-12-011110.3389/fvets.2024.14644321464432The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in ratSepide Behrouz0Sepide Behrouz1Mahla Mohammadi2Hadi Sarir3Mohammad Hossein Boskabady4Mohammad Hossein Boskabady5Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, IranApplied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranBackgroundThe effects of camel milk in inflammation and systemic oxidative stress of cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) associated with small airway inflammation in rats were investigated.Methods35 male Wistar rats were randomly divided into five groups: (a) control, (b) CS-exposed rats, c and (d) CS-exposed rats treated with the 4 and 8 mL/kg camel milk, and (e) CS-exposed rats treated with 1 mg/kg dexamethasone.ResultsTotal and differential WBC counts, serum level of TNF-α and malondialdehyde (MDA) level in serum and homogenized tissues of the heart, kidney, liver, and testicle were significantly increased, but catalase (CAT), superoxide dismutase (SOD) and thiol levels were significantly decreased in CS-exposed rats (p < 0.01 to p < 0.001). Treatment with dexamethasone and both doses of camel milk improved all measured variables compared to the COPD group (p < 0.05 to p < 0.001). The improvements of most variables in the treated group with high dose of camel milk were higher than the effect of dexamethasone (p < 0.05 to p < 0.001). These findings suggest that camel milk has a therapeutic potential for treating systemic oxidative stress and inflammatory induced by CS.ConclusionTherefore, camel milk might be effective in attenuating the effects of CS-induced systemic inflammation and oxidative stress.https://www.frontiersin.org/articles/10.3389/fvets.2024.1464432/fullcamel milkCOPDcytokineoxidative stresspulmonary disease |
| spellingShingle | Sepide Behrouz Sepide Behrouz Mahla Mohammadi Hadi Sarir Mohammad Hossein Boskabady Mohammad Hossein Boskabady The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat Frontiers in Veterinary Science camel milk COPD cytokine oxidative stress pulmonary disease |
| title | The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat |
| title_full | The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat |
| title_fullStr | The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat |
| title_full_unstemmed | The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat |
| title_short | The effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke-induced chronic obstructive pulmonary disease model in rat |
| title_sort | effects of camel milk in systemic inflammation and oxidative stress of cigarette smoke induced chronic obstructive pulmonary disease model in rat |
| topic | camel milk COPD cytokine oxidative stress pulmonary disease |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2024.1464432/full |
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