From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health

From a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health

Tetramethylpyrazine (TMP), a bioactive alkaloid isolated from the traditional Chinese medicine Ligusticum wallichii (Chuanxiong), has gained significant attention for its therapeutic potential in cerebrovascular diseases and cognitive impairment, mainly due to its antioxidant, anti-inflammatory, and...

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Bibliographic Details
Main Authors:	Xiaodi Wang, Muhan Cao, Yi Xu, Xifei Yang, Qinghua Hou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Pharmacology
Subjects:	tetramethylpyrazine pharmacology pharmacodynamics structure-activity relationships cerebrovascular function cognition
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1653056/full
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