Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors

Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors

Background Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy against solid tumors.M...

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Bibliographic Details
Main Authors: Lu Wang, Li Ding, Gang Chen, Zhou Xu, Yanqing Zhang, Bin Deng, Xiya Wang, Yemin Xu, Mengyue Wu, Yinhe Xia, Zhennan Cao, Ruilong Song
Format: Article
Language:English
Published: BMJ Publishing Group 2025-01-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/1/e010403.full
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