Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease

Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease

Abstract Background Alzheimer's disease (AD) is a growing healthcare crisis with limited effective therapies. This study aims to identify new candidate drugs that can be repurposed using key transcriptional regulators (DERs) in AD as therapeutic targets. Methods Multi‐cohort single‐nucleus RNA...

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Bibliographic Details
Main Authors: Martin Nwadiugwu, Md Selim Reza, Boluwatife Afolabi, Demetrius M. Maraganore, Hui Shen, Hongwen Deng
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Clinical and Translational Medicine
Subjects:
Alzheimer's disease
drug repurposing
gene regulators
Lasmiditan
snRNA‐Seq
Online Access:https://doi.org/10.1002/ctm2.70443
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https://doi.org/10.1002/ctm2.70443

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