Sustained yet non-curative response to lenalidomide in relapsed angioimmunoblastic T-cell lymphoma with acquired chidamide resistance: a case report with 10-year follow-up, genetic insights and literature review

Sustained yet non-curative response to lenalidomide in relapsed angioimmunoblastic T-cell lymphoma with acquired chidamide resistance: a case report with 10-year follow-up, genetic insights and literature review

Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive subtype of peripheral T-cell lymphoma (PTCL) characterized by its T-follicular helper (TFH) phenotype. Relapsed and refractory disease is common in AITL and often associated with a poor prognosis. The presence of epigenetic abnormalities, im...

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Bibliographic Details
Main Authors: Juan Xu, Jie Huang, Liping Xie, Ting Liu, Jianjun Li, Xinchuan Chen, Zhigang Liu, Sha Zhao, Caigang Xu, Yu Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Oncology
Subjects:
angioimmunoblastic T-cell lymphoma
relapsed
lenalidomide
chidamide
resistance
immune dysregulation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1471090/full
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