Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family”
Due to their interactions with the neoplasm, platelets undergo various proteomic and transcriptomic modifications, resulting in the development of what is known as the “Tumor-Educated Platelets (TEPs) phenotype”. Consequently, in addition to their suitability for Liquid Biopsy (LB) applications, the...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | The Journal of Liquid Biopsy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950195424000018 |
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| author | Andrea Gottardo Valerio Gristina Alessandro Perez Emilia Di Giovanni Silvia Contino Nadia Barraco Marco Bono Giuliana Iannì Ugo Randazzo Tancredi Didier Bazan Russo Federica Iacono Lorena Incorvaia Giuseppe Badalamenti Antonio Russo Antonio Galvano Viviana Bazan |
| author_facet | Andrea Gottardo Valerio Gristina Alessandro Perez Emilia Di Giovanni Silvia Contino Nadia Barraco Marco Bono Giuliana Iannì Ugo Randazzo Tancredi Didier Bazan Russo Federica Iacono Lorena Incorvaia Giuseppe Badalamenti Antonio Russo Antonio Galvano Viviana Bazan |
| author_sort | Andrea Gottardo |
| collection | DOAJ |
| description | Due to their interactions with the neoplasm, platelets undergo various proteomic and transcriptomic modifications, resulting in the development of what is known as the “Tumor-Educated Platelets (TEPs) phenotype”. Consequently, in addition to their suitability for Liquid Biopsy (LB) applications, they play a pivotal role in the malignancy by communicating with Circulating Tumor Cells (CTCs), Tumor Microenvironment (TME), and the tumor itself through multiple mechanisms and at multiple levels, ultimately promoting the metastasis of cancer. Therefore, this Systematic Review of MEDLINE and the Cochrane Library present in-depth insights into these phenomena, with the aim of enhancing the understanding of the complex interplay between TEPs and Non-Small Cell Lung Cancer (NSCLC). This endeavor serves to provide context and drive medical research efforts, which are increasingly focused on developing novel diagnostic and therapeutic technologies that leverage the specific binding of these platelets to the disease. |
| format | Article |
| id | doaj-art-dddd0f9d5e4a484080397e21e6b4c8f6 |
| institution | Kabale University |
| issn | 2950-1954 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Liquid Biopsy |
| spelling | doaj-art-dddd0f9d5e4a484080397e21e6b4c8f62024-11-22T07:41:27ZengElsevierThe Journal of Liquid Biopsy2950-19542024-03-013100136Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family”Andrea Gottardo0Valerio Gristina1Alessandro Perez2Emilia Di Giovanni3Silvia Contino4Nadia Barraco5Marco Bono6Giuliana Iannì7Ugo Randazzo8Tancredi Didier Bazan Russo9Federica Iacono10Lorena Incorvaia11Giuseppe Badalamenti12Antonio Russo13Antonio Galvano14Viviana Bazan15Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, Italy; Corresponding author. Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), ''P. Giaccone'' University Hospital (A.O.U.P.) of Palermo, Via del Vespro 129, 90127, Palermo, Italy.Department of Surgical, Oncological and Oral Sciences (Di.Chir.On.S.), University of Palermo, Palermo, ItalyDepartment of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University of Palermo, Palermo, ItalyDue to their interactions with the neoplasm, platelets undergo various proteomic and transcriptomic modifications, resulting in the development of what is known as the “Tumor-Educated Platelets (TEPs) phenotype”. Consequently, in addition to their suitability for Liquid Biopsy (LB) applications, they play a pivotal role in the malignancy by communicating with Circulating Tumor Cells (CTCs), Tumor Microenvironment (TME), and the tumor itself through multiple mechanisms and at multiple levels, ultimately promoting the metastasis of cancer. Therefore, this Systematic Review of MEDLINE and the Cochrane Library present in-depth insights into these phenomena, with the aim of enhancing the understanding of the complex interplay between TEPs and Non-Small Cell Lung Cancer (NSCLC). This endeavor serves to provide context and drive medical research efforts, which are increasingly focused on developing novel diagnostic and therapeutic technologies that leverage the specific binding of these platelets to the disease.http://www.sciencedirect.com/science/article/pii/S2950195424000018TEPNSCLCLiquid biopsyTumor biologyCTCTME |
| spellingShingle | Andrea Gottardo Valerio Gristina Alessandro Perez Emilia Di Giovanni Silvia Contino Nadia Barraco Marco Bono Giuliana Iannì Ugo Randazzo Tancredi Didier Bazan Russo Federica Iacono Lorena Incorvaia Giuseppe Badalamenti Antonio Russo Antonio Galvano Viviana Bazan Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family” The Journal of Liquid Biopsy TEP NSCLC Liquid biopsy Tumor biology CTC TME |
| title | Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family” |
| title_full | Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family” |
| title_fullStr | Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family” |
| title_full_unstemmed | Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family” |
| title_short | Roles of Tumor-Educated Platelets (TEPs) in the biology of Non-Small Cell Lung Cancer (NSCLC): A systematic review. “Re-discovering the neglected biosources of the liquid biopsy family” |
| title_sort | roles of tumor educated platelets teps in the biology of non small cell lung cancer nsclc a systematic review re discovering the neglected biosources of the liquid biopsy family |
| topic | TEP NSCLC Liquid biopsy Tumor biology CTC TME |
| url | http://www.sciencedirect.com/science/article/pii/S2950195424000018 |
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