Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients

Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients

Abstract Plasma extracellular vesicles (EVs) are cell-derived lipid particles and reportedly play a role in sepsis pathogenesis. This study aimed to identify EV cargo proteins in septic patients and explore their association with key sepsis pathophysiology. Plasma EVs were subjected to Tandem Mass T...

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Bibliographic Details
Main Authors: Chanhee Park, Taekyung Ryu, Rashida Mohamed-Hinds, Kyungdo Kim, Jin Hyeok Kim, Lin Zou, Brittney Williams, Chan Hyun Na, Wei Chao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sepsis
Extracellular vesicles (EVs)
Mass spectrometry
Proteomics
Tandem mass Tag (TMT)
Online Access:https://doi.org/10.1038/s41598-025-06430-x
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