Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain
IntroductionWe investigated the neural correlates of cognitive decline in visual word perception from the perspective of intrinsic brain networks.MethodsA total of 19 healthy older adults and 22 young adults were recruited to participate in two functional magnetic resonance imaging (fMRI) sessions (...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1483449/full |
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| author | Licheng Xue Tianying Qing Yating Lv Yating Lv Jing Zhao Jing Zhao Jing Zhao |
| author_facet | Licheng Xue Tianying Qing Yating Lv Yating Lv Jing Zhao Jing Zhao Jing Zhao |
| author_sort | Licheng Xue |
| collection | DOAJ |
| description | IntroductionWe investigated the neural correlates of cognitive decline in visual word perception from the perspective of intrinsic brain networks.MethodsA total of 19 healthy older adults and 22 young adults were recruited to participate in two functional magnetic resonance imaging (fMRI) sessions (one resting-state session and one for localizer tasks), along with a visual word perceptual processing task. We examined age-related alterations in resting-state functional connectivity (FC) within the word network, as well as between the word network and other networks. We tested their associations with behavioral performance in word and symbol-form processing.ResultsWe found that, compared to young adults, older adults exhibited increased FC between the two word-selective regions in the left and right ventral occipitotemporal cortex (vOT). Additionally, older adults exhibited increased FC between these two word-selective regions and non-word-selective regions. Notably, these FC alterations correlated with individual differences in behavioral performance in visual word perception.DiscussionThese results suggest that cognitive decline in visual word perception is associated with decreased segregation within and beyond the word network in the aging brain. Our findings support the neural dedifferentiation hypothesis for cognitive decline in visual word processing and improve our understanding of interactive neural specialization theory. |
| format | Article |
| id | doaj-art-ddc2c1df677842d2a6ccdf9da7e152c8 |
| institution | Kabale University |
| issn | 1663-4365 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-ddc2c1df677842d2a6ccdf9da7e152c82024-12-05T06:28:40ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652024-12-011610.3389/fnagi.2024.14834491483449Aging of visual word perception is related to decreased segregation within and beyond the word network in the brainLicheng Xue0Tianying Qing1Yating Lv2Yating Lv3Jing Zhao4Jing Zhao5Jing Zhao6School of Early Childhood Education, Hangzhou Polytechnic, Zhejiang, ChinaHelmholtz Institute, Utrecht University, Utrecht, NetherlandsCenter for Cognition and Brain Disorders, The Affiliated Hospital of Hangzhou Normal University, Zhejiang, ChinaZhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Zhejiang, ChinaZhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Zhejiang, ChinaJing Hengyi School of Education, Hangzhou Normal University, Zhejiang, ChinaZhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare, Hangzhou Normal University, Zhejiang, ChinaIntroductionWe investigated the neural correlates of cognitive decline in visual word perception from the perspective of intrinsic brain networks.MethodsA total of 19 healthy older adults and 22 young adults were recruited to participate in two functional magnetic resonance imaging (fMRI) sessions (one resting-state session and one for localizer tasks), along with a visual word perceptual processing task. We examined age-related alterations in resting-state functional connectivity (FC) within the word network, as well as between the word network and other networks. We tested their associations with behavioral performance in word and symbol-form processing.ResultsWe found that, compared to young adults, older adults exhibited increased FC between the two word-selective regions in the left and right ventral occipitotemporal cortex (vOT). Additionally, older adults exhibited increased FC between these two word-selective regions and non-word-selective regions. Notably, these FC alterations correlated with individual differences in behavioral performance in visual word perception.DiscussionThese results suggest that cognitive decline in visual word perception is associated with decreased segregation within and beyond the word network in the aging brain. Our findings support the neural dedifferentiation hypothesis for cognitive decline in visual word processing and improve our understanding of interactive neural specialization theory.https://www.frontiersin.org/articles/10.3389/fnagi.2024.1483449/fullagingvisual word processingfunctional connectivityresting-state fMRIneural dedifferentiation hypothesis |
| spellingShingle | Licheng Xue Tianying Qing Yating Lv Yating Lv Jing Zhao Jing Zhao Jing Zhao Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain Frontiers in Aging Neuroscience aging visual word processing functional connectivity resting-state fMRI neural dedifferentiation hypothesis |
| title | Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain |
| title_full | Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain |
| title_fullStr | Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain |
| title_full_unstemmed | Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain |
| title_short | Aging of visual word perception is related to decreased segregation within and beyond the word network in the brain |
| title_sort | aging of visual word perception is related to decreased segregation within and beyond the word network in the brain |
| topic | aging visual word processing functional connectivity resting-state fMRI neural dedifferentiation hypothesis |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2024.1483449/full |
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