Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults
Abstract Hemodynamic forces (HDF), which reflect the forces exchanged between blood and cardiac tissues, can be derived from cardiac magnetic resonance (CMR) or transthoracic echocardiography (TTE). Although normal values are reported for each imaging technique, no study has compared HDF values with...
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Nature Portfolio
2025-08-01
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| Online Access: | https://doi.org/10.1038/s41598-025-13966-5 |
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| author | Aizhan Zhankorazova Giovanni Tonti Zaukiya Khamitova Bauyrzhan Toktarbay Dinara Jumadilova Makhabbat Bekbossynova Nail Khissamutdinov Tairkhan Dautov Alessandro Salustri |
| author_facet | Aizhan Zhankorazova Giovanni Tonti Zaukiya Khamitova Bauyrzhan Toktarbay Dinara Jumadilova Makhabbat Bekbossynova Nail Khissamutdinov Tairkhan Dautov Alessandro Salustri |
| author_sort | Aizhan Zhankorazova |
| collection | DOAJ |
| description | Abstract Hemodynamic forces (HDF), which reflect the forces exchanged between blood and cardiac tissues, can be derived from cardiac magnetic resonance (CMR) or transthoracic echocardiography (TTE). Although normal values are reported for each imaging technique, no study has compared HDF values within the same cohort so far. We aimed to compare left ventricular (LV) HDF parameters obtained from CMR and TTE in healthy subjects. Twenty volunteers underwent both cine-CMR and 2D-TTE (within 7 days) at the Heart Center University Medical Center in Astana, Kazakhstan. Images were analyzed offline using dedicated software to extract standard volumetric, functional, strain, and HDF parameters: longitudinal (A-B) and transverse (L-S) HDF, L-S/A-B HDF ratio, and HDF vector angle. Statistical comparisons were performed with significance set at p < 0.05; Bland–Altman plots assessed agreement. TTE significantly underestimated LV volumes, ejection fraction, and global longitudinal strain compared to CMR. Similarly, HDF values were lower with TTE for both longitudinal and transverse forces (A-B HDF: 12.4 ± 3.4 vs. 26.1 ± 6.6; L-S HDF: 2.6 ± 1.2 vs. 5.2 ± 1.4; both p < 0.001). Bland–Altman analysis confirmed systematic underestimation of HDF by TTE. These findings suggest that TTE and CMR cannot be used interchangeably for HDF assessment, particularly in serial studies. |
| format | Article |
| id | doaj-art-ddba49e6a2a64aacb37f6322f3faf4aa |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-ddba49e6a2a64aacb37f6322f3faf4aa2025-08-20T04:03:01ZengNature PortfolioScientific Reports2045-23222025-08-0115111010.1038/s41598-025-13966-5Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adultsAizhan Zhankorazova0Giovanni Tonti1Zaukiya Khamitova2Bauyrzhan Toktarbay3Dinara Jumadilova4Makhabbat Bekbossynova5Nail Khissamutdinov6Tairkhan Dautov7Alessandro Salustri8School of Medicine, Nazarbayev UniversityDepartment of Cardiovascular Disease, University G. D’AnnunzioSchool of Medicine, Nazarbayev UniversitySchool of Medicine, Nazarbayev UniversitySchool of Medicine, Nazarbayev UniversityHeart Center, University Medical CenterHeart Center, University Medical CenterClinical and Academic Department of Radiology and Nuclear Medicine, University Medical CenterSchool of Medicine, Nazarbayev UniversityAbstract Hemodynamic forces (HDF), which reflect the forces exchanged between blood and cardiac tissues, can be derived from cardiac magnetic resonance (CMR) or transthoracic echocardiography (TTE). Although normal values are reported for each imaging technique, no study has compared HDF values within the same cohort so far. We aimed to compare left ventricular (LV) HDF parameters obtained from CMR and TTE in healthy subjects. Twenty volunteers underwent both cine-CMR and 2D-TTE (within 7 days) at the Heart Center University Medical Center in Astana, Kazakhstan. Images were analyzed offline using dedicated software to extract standard volumetric, functional, strain, and HDF parameters: longitudinal (A-B) and transverse (L-S) HDF, L-S/A-B HDF ratio, and HDF vector angle. Statistical comparisons were performed with significance set at p < 0.05; Bland–Altman plots assessed agreement. TTE significantly underestimated LV volumes, ejection fraction, and global longitudinal strain compared to CMR. Similarly, HDF values were lower with TTE for both longitudinal and transverse forces (A-B HDF: 12.4 ± 3.4 vs. 26.1 ± 6.6; L-S HDF: 2.6 ± 1.2 vs. 5.2 ± 1.4; both p < 0.001). Bland–Altman analysis confirmed systematic underestimation of HDF by TTE. These findings suggest that TTE and CMR cannot be used interchangeably for HDF assessment, particularly in serial studies.https://doi.org/10.1038/s41598-025-13966-5Hemodynamic forcesEchocardiographyCardiac magnetic resonance |
| spellingShingle | Aizhan Zhankorazova Giovanni Tonti Zaukiya Khamitova Bauyrzhan Toktarbay Dinara Jumadilova Makhabbat Bekbossynova Nail Khissamutdinov Tairkhan Dautov Alessandro Salustri Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults Scientific Reports Hemodynamic forces Echocardiography Cardiac magnetic resonance |
| title | Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults |
| title_full | Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults |
| title_fullStr | Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults |
| title_full_unstemmed | Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults |
| title_short | Comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults |
| title_sort | comparison of left ventricular hemodynamic forces measured by transthoracic echocardiography and cardiac magnetic resonance imaging in healthy adults |
| topic | Hemodynamic forces Echocardiography Cardiac magnetic resonance |
| url | https://doi.org/10.1038/s41598-025-13966-5 |
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