A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database
Abstract Background This study utilizes the FDA Adverse Event Reporting System (FAERS) database to compare the adverse reaction signals of cyclosporine and tacrolimus, two widely used immunosuppressants, in relation to drug-induced kidney injury. The findings aim to inform clinical decision-making....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-05-01
|
| Series: | BMC Immunology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12865-025-00714-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849314732041830400 |
|---|---|
| author | Min Xu Shanggang Xu Xueliang Yi |
| author_facet | Min Xu Shanggang Xu Xueliang Yi |
| author_sort | Min Xu |
| collection | DOAJ |
| description | Abstract Background This study utilizes the FDA Adverse Event Reporting System (FAERS) database to compare the adverse reaction signals of cyclosporine and tacrolimus, two widely used immunosuppressants, in relation to drug-induced kidney injury. The findings aim to inform clinical decision-making. Methods The study retrospectively analyzed data from January 2004 to September 2024, employing both frequency analysis and Bayesian methods. We assessed and compared the mortality rates, hospitalization rates, and the association of cyclosporine and tacrolimus with kidney injury to elucidate the renal toxicity of these two drugs. Results After data processing, we identified a total of 3,449 cyclosporine-related kidney injury reports and 5,538 tacrolimus-related kidney injury reports. The results revealed a stronger association between tacrolimus and kidney injury. Additionally, kidney injuries associated with both cyclosporine and tacrolimus predominantly affected males. Furthermore, the hospitalization rate for cyclosporine-related kidney injury was 34.40%, compared to 44.50% for tacrolimus. The mortality rate associated with cyclosporine-induced kidney injury was higher than that of tacrolimus. Conclusion This study utilized the FDA Adverse Event Reporting System (FAERS) database from January 2004 to September 2024 to perform a comprehensive analysis of adverse drug-related kidney injury reactions to cyclosporine and tacrolimus. The results suggest that both cyclosporine and tacrolimus are associated with renal injury, but tacrolimus appears to reduce mortality while increasing hospitalization rates. This serves as a critical warning for planning future treatment regimens, drug monitoring, and reducing adverse effects. |
| format | Article |
| id | doaj-art-dd7ccbe70b924c118e1dfa75a05fd2a1 |
| institution | Kabale University |
| issn | 1471-2172 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Immunology |
| spelling | doaj-art-dd7ccbe70b924c118e1dfa75a05fd2a12025-08-20T03:52:20ZengBMCBMC Immunology1471-21722025-05-0126111110.1186/s12865-025-00714-7A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS databaseMin Xu0Shanggang Xu1Xueliang Yi2Department of Respiratory, Clinical Medical College & Affliated Hospital of Chengdu University, Chengdu UniversityDepartment of Emergency, Clinical Medical College & Affliated Hospital of Chengdu University, Chengdu UniversityDepartment of Emergency, Clinical Medical College & Affliated Hospital of Chengdu University, Chengdu UniversityAbstract Background This study utilizes the FDA Adverse Event Reporting System (FAERS) database to compare the adverse reaction signals of cyclosporine and tacrolimus, two widely used immunosuppressants, in relation to drug-induced kidney injury. The findings aim to inform clinical decision-making. Methods The study retrospectively analyzed data from January 2004 to September 2024, employing both frequency analysis and Bayesian methods. We assessed and compared the mortality rates, hospitalization rates, and the association of cyclosporine and tacrolimus with kidney injury to elucidate the renal toxicity of these two drugs. Results After data processing, we identified a total of 3,449 cyclosporine-related kidney injury reports and 5,538 tacrolimus-related kidney injury reports. The results revealed a stronger association between tacrolimus and kidney injury. Additionally, kidney injuries associated with both cyclosporine and tacrolimus predominantly affected males. Furthermore, the hospitalization rate for cyclosporine-related kidney injury was 34.40%, compared to 44.50% for tacrolimus. The mortality rate associated with cyclosporine-induced kidney injury was higher than that of tacrolimus. Conclusion This study utilized the FDA Adverse Event Reporting System (FAERS) database from January 2004 to September 2024 to perform a comprehensive analysis of adverse drug-related kidney injury reactions to cyclosporine and tacrolimus. The results suggest that both cyclosporine and tacrolimus are associated with renal injury, but tacrolimus appears to reduce mortality while increasing hospitalization rates. This serves as a critical warning for planning future treatment regimens, drug monitoring, and reducing adverse effects.https://doi.org/10.1186/s12865-025-00714-7CyclosporineTacrolimusKidney injuryAdverse drug eventsFDA adverse event reporting systemReal-world analysis |
| spellingShingle | Min Xu Shanggang Xu Xueliang Yi A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database BMC Immunology Cyclosporine Tacrolimus Kidney injury Adverse drug events FDA adverse event reporting system Real-world analysis |
| title | A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database |
| title_full | A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database |
| title_fullStr | A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database |
| title_full_unstemmed | A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database |
| title_short | A comparative analysis of drug-induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the FAERS database |
| title_sort | comparative analysis of drug induced kidney injury adverse reactions between cyclosporine and tacrolimus based on the faers database |
| topic | Cyclosporine Tacrolimus Kidney injury Adverse drug events FDA adverse event reporting system Real-world analysis |
| url | https://doi.org/10.1186/s12865-025-00714-7 |
| work_keys_str_mv | AT minxu acomparativeanalysisofdruginducedkidneyinjuryadversereactionsbetweencyclosporineandtacrolimusbasedonthefaersdatabase AT shanggangxu acomparativeanalysisofdruginducedkidneyinjuryadversereactionsbetweencyclosporineandtacrolimusbasedonthefaersdatabase AT xueliangyi acomparativeanalysisofdruginducedkidneyinjuryadversereactionsbetweencyclosporineandtacrolimusbasedonthefaersdatabase AT minxu comparativeanalysisofdruginducedkidneyinjuryadversereactionsbetweencyclosporineandtacrolimusbasedonthefaersdatabase AT shanggangxu comparativeanalysisofdruginducedkidneyinjuryadversereactionsbetweencyclosporineandtacrolimusbasedonthefaersdatabase AT xueliangyi comparativeanalysisofdruginducedkidneyinjuryadversereactionsbetweencyclosporineandtacrolimusbasedonthefaersdatabase |