Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue)
In the title molecule, C13H17N3O3, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C—H...O hydrogen bonds form chains of molecules extending along the c-axis direction, which a...
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| Format: | Article |
| Language: | English |
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International Union of Crystallography
2025-01-01
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| Series: | Acta Crystallographica Section E: Crystallographic Communications |
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| Online Access: | https://journals.iucr.org/paper?S205698902401185X |
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| author | Imane Maimoune Benson M. Kariuki Abderrazzak El Moutaouakil Ala Allah Intissar Nchioua Abdulsalam Alsubari Joel T. Mague Abdelkader Zarrouk Youssef Ramli |
| author_facet | Imane Maimoune Benson M. Kariuki Abderrazzak El Moutaouakil Ala Allah Intissar Nchioua Abdulsalam Alsubari Joel T. Mague Abdelkader Zarrouk Youssef Ramli |
| author_sort | Imane Maimoune |
| collection | DOAJ |
| description | In the title molecule, C13H17N3O3, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C—H...O hydrogen bonds form chains of molecules extending along the c-axis direction, which are linked by C=O...π(ring) interactions. A Hirshfeld surface analysis showed the majority of intermolecular interactions to be H...H contacts while O...H/H...O contacts are the second most numerous. |
| format | Article |
| id | doaj-art-dd6ee61c92084743809a3ac4c7559732 |
| institution | Kabale University |
| issn | 2056-9890 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | International Union of Crystallography |
| record_format | Article |
| series | Acta Crystallographica Section E: Crystallographic Communications |
| spelling | doaj-art-dd6ee61c92084743809a3ac4c75597322025-01-06T09:23:11ZengInternational Union of CrystallographyActa Crystallographica Section E: Crystallographic Communications2056-98902025-01-01811697310.1107/S205698902401185Xvm2309Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue)Imane Maimoune0Benson M. Kariuki1Abderrazzak El Moutaouakil Ala Allah2Intissar Nchioua3Abdulsalam Alsubari4Joel T. Mague5Abdelkader Zarrouk6Youssef Ramli7Laboratory of Materials Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, PO Box 1014, Rabat, MoroccoSchool of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United KingdomLaboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, MoroccoLaboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, MoroccoLaboratory of Medicinal Chemistry, Faculty of Clinical Pharmacy, 21 September University, YemenDepartment of Chemistry, Tulane University, New Orleans, LA 70118, USALaboratory of Materials Nanotechnology and Environment, Faculty of Sciences, Mohammed V University in Rabat, PO Box 1014, Rabat, MoroccoLaboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, MoroccoIn the title molecule, C13H17N3O3, the substituents on the phenyl ring are rotated slightly out of the mean plane of the ring but the piperidine moiety is nearly perpendicular to that plane. In the crystal, C—H...O hydrogen bonds form chains of molecules extending along the c-axis direction, which are linked by C=O...π(ring) interactions. A Hirshfeld surface analysis showed the majority of intermolecular interactions to be H...H contacts while O...H/H...O contacts are the second most numerous.https://journals.iucr.org/paper?S205698902401185Xcrystal structureacetamidepiperidinehydrogen bondc=o...π(ring) interaction |
| spellingShingle | Imane Maimoune Benson M. Kariuki Abderrazzak El Moutaouakil Ala Allah Intissar Nchioua Abdulsalam Alsubari Joel T. Mague Abdelkader Zarrouk Youssef Ramli Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue) Acta Crystallographica Section E: Crystallographic Communications crystal structure acetamide piperidine hydrogen bond c=o...π(ring) interaction |
| title | Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue) |
| title_full | Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue) |
| title_fullStr | Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue) |
| title_full_unstemmed | Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue) |
| title_short | Crystal structure and Hirshfeld surface analysis of N-(4-nitrophenyl)-2-(piperidin-1-yl)acetamide (lidocaine analogue) |
| title_sort | crystal structure and hirshfeld surface analysis of n 4 nitrophenyl 2 piperidin 1 yl acetamide lidocaine analogue |
| topic | crystal structure acetamide piperidine hydrogen bond c=o...π(ring) interaction |
| url | https://journals.iucr.org/paper?S205698902401185X |
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