Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration
Osteoarthritis (OA) is a prevalent joint disorder characterized by progressive cartilage degradation, impaired mesenchymal stem cell (MSC) function, and chronic inflammation, ultimately leading to irreversible structural damage and functional impairment. Despite its high global burden, no regulatory...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425006702 |
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| author | Ruizhe Zhao Bing Liang Yijie Shi Jianfei Gao Xuezhe Wang Tianyi Shao Kunyue Xing Mingzhe Yan Tianrui Wang Yingze Zhang Dongming Xing |
| author_facet | Ruizhe Zhao Bing Liang Yijie Shi Jianfei Gao Xuezhe Wang Tianyi Shao Kunyue Xing Mingzhe Yan Tianrui Wang Yingze Zhang Dongming Xing |
| author_sort | Ruizhe Zhao |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a prevalent joint disorder characterized by progressive cartilage degradation, impaired mesenchymal stem cell (MSC) function, and chronic inflammation, ultimately leading to irreversible structural damage and functional impairment. Despite its high global burden, no regulatory agency has yet approved a disease-modifying therapy for OA, and effective interventions to halt or delay its progression remain a major challenge. Recent research highlights the pivotal role of the immune system in OA pathogenesis, with immunomodulatory biomaterials emerging as a promising strategy to simultaneously regulate inflammatory responses and promote tissue regeneration. These biomaterials, by leveraging their biocompatibility and immunoregulatory properties, offer a transformative alternative to conventional OA therapies, which predominantly focus on symptom management rather than targeting the underlying disease mechanisms. In this review, we comprehensively examine various immunomodulatory biomaterial strategies designed to mitigate OA progression. We first elucidate the immune landscape of OA, detailing the interplay between inflammation and disease pathophysiology. Next, we explore the latest advancements in immunomodulatory biomaterials, including nanoparticles (NPs), hydrogels, and scaffolds, highlighting their potential to reshape OA treatment. Finally, we discuss existing challenges and propose future directions for optimizing biomaterial-based immunotherapies to enhance OA management. |
| format | Article |
| id | doaj-art-dd6ba4be0fb74e0da2d79f34f1b94e0b |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-dd6ba4be0fb74e0da2d79f34f1b94e0b2025-08-20T03:31:40ZengElsevierMaterials Today Bio2590-00642025-10-013410210010.1016/j.mtbio.2025.102100Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regenerationRuizhe Zhao0Bing Liang1Yijie Shi2Jianfei Gao3Xuezhe Wang4Tianyi Shao5Kunyue Xing6Mingzhe Yan7Tianrui Wang8Yingze Zhang9Dongming Xing10Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Qingdao College of Medicine, Qingdao University, Qingdao, 266003, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Qingdao College of Medicine, Qingdao University, Qingdao, 266003, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Qingdao College of Medicine, Qingdao University, Qingdao, 266003, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Qingdao College of Medicine, Qingdao University, Qingdao, 266003, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Qingdao College of Medicine, Qingdao University, Qingdao, 266003, ChinaCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Qingdao College of Medicine, Qingdao University, Qingdao, 266003, ChinaUCL Institute of Health Informatics, University College London, Gower Street, London, WC1E 6BT, UKCancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; Corresponding author.Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266000, China; Orthopaedic Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China; Corresponding author. Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266000, China.Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266000, China; Orthopaedic Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, 266000, China; Corresponding author. Department of Orthopedics, Affiliated Hospital of Qingdao University, Qingdao, 266000, China.Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China; School of Life Sciences, Tsinghua University, Beijing, 100084, China; Corresponding author. Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, 266000, China.Osteoarthritis (OA) is a prevalent joint disorder characterized by progressive cartilage degradation, impaired mesenchymal stem cell (MSC) function, and chronic inflammation, ultimately leading to irreversible structural damage and functional impairment. Despite its high global burden, no regulatory agency has yet approved a disease-modifying therapy for OA, and effective interventions to halt or delay its progression remain a major challenge. Recent research highlights the pivotal role of the immune system in OA pathogenesis, with immunomodulatory biomaterials emerging as a promising strategy to simultaneously regulate inflammatory responses and promote tissue regeneration. These biomaterials, by leveraging their biocompatibility and immunoregulatory properties, offer a transformative alternative to conventional OA therapies, which predominantly focus on symptom management rather than targeting the underlying disease mechanisms. In this review, we comprehensively examine various immunomodulatory biomaterial strategies designed to mitigate OA progression. We first elucidate the immune landscape of OA, detailing the interplay between inflammation and disease pathophysiology. Next, we explore the latest advancements in immunomodulatory biomaterials, including nanoparticles (NPs), hydrogels, and scaffolds, highlighting their potential to reshape OA treatment. Finally, we discuss existing challenges and propose future directions for optimizing biomaterial-based immunotherapies to enhance OA management.http://www.sciencedirect.com/science/article/pii/S2590006425006702Immunomodulatory biomaterialsOsteoarthritisCartilage regenerationImmune responseResponsive biomaterialsDrug delivery |
| spellingShingle | Ruizhe Zhao Bing Liang Yijie Shi Jianfei Gao Xuezhe Wang Tianyi Shao Kunyue Xing Mingzhe Yan Tianrui Wang Yingze Zhang Dongming Xing Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration Materials Today Bio Immunomodulatory biomaterials Osteoarthritis Cartilage regeneration Immune response Responsive biomaterials Drug delivery |
| title | Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration |
| title_full | Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration |
| title_fullStr | Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration |
| title_full_unstemmed | Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration |
| title_short | Immunomodulatory biomaterials for osteoarthritis: Targeting inflammation and enhancing cartilage regeneration |
| title_sort | immunomodulatory biomaterials for osteoarthritis targeting inflammation and enhancing cartilage regeneration |
| topic | Immunomodulatory biomaterials Osteoarthritis Cartilage regeneration Immune response Responsive biomaterials Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425006702 |
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