Generation and characterization of CRISPR-Cas9-mediated XPC gene knockout in human skin cells
Abstract Xeroderma pigmentosum group C (XPC) is a versatile protein crucial for sensing DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. This pathway is vital for mammalian cells, acting as their essential approach for repairing DNA lesions stemming from interactions with...
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Main Authors: | Ali Nasrallah, Hamid-Reza Rezvani, Farah Kobaisi, Ahmad Hammoud, Jérôme Rambert, Jos P. H. Smits, Eric Sulpice, Walid Rachidi |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-12-01
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Series: | Scientific Reports |
Subjects: | |
Online Access: | https://doi.org/10.1038/s41598-024-81675-6 |
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