Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects
Gouty arthritis (GA) is a type of inflammatory arthritis caused by the deposition of monosodium urate crystals. Current clinical therapies fail to simultaneously reduce uric acid (UA) levels and alleviate inflammation. Previous studies have demonstrated that Euglena (Eug) polysaccharides can effecti...
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KeAi Communications Co., Ltd.
2025-10-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25002154 |
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| author | Xiaoyang Liu Jia Dong Zhongshu Wu Jiarong Cui Yixin Zheng Min Zhou |
| author_facet | Xiaoyang Liu Jia Dong Zhongshu Wu Jiarong Cui Yixin Zheng Min Zhou |
| author_sort | Xiaoyang Liu |
| collection | DOAJ |
| description | Gouty arthritis (GA) is a type of inflammatory arthritis caused by the deposition of monosodium urate crystals. Current clinical therapies fail to simultaneously reduce uric acid (UA) levels and alleviate inflammation. Previous studies have demonstrated that Euglena (Eug) polysaccharides can effectively adsorb UA. Colchicine (Col), the most prescribed medication for GA, exhibits anti-inflammatory effects but is associated with significant side effects. Here, we developed an oral microalgae-based hydrogel system (Eug-Col@Fucar) utilizing Fucar to load the Eug-Col complex, aiming to synergistically reduce UA levels and alleviate inflammation in GA treatment. Eug-Col@Fucar regulated release characteristics and enhanced intestinal retention, thereby mitigating the side effects associated with oral Col. The oral administration of Eug-Col@Fucar could inhibit the progression of GA by eliminating reactive oxygen species, reprogramming the inflammatory microenvironment to promote cell polarization towards M2-like anti-inflammatory cells, inhibiting the NLRP3-IL-1β pathway, and reducing the expression of pro-inflammatory factors. Additionally, Eug-Col@Fucar improved bile acid metabolism in vivo, alleviating the intestinal-hepatic circulation damage caused by Col. This study presents a safe, simple, and highly effective treatment strategy for managing GA and alleviating the gastrointestinal side effects that arise from the long-term administration of Col, demonstrating clinical practicability. |
| format | Article |
| id | doaj-art-dcf817572df34b18aec3e3c1d1a7d4d0 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-10-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Bioactive Materials |
| spelling | doaj-art-dcf817572df34b18aec3e3c1d1a7d4d02025-08-24T05:13:35ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-10-0152173510.1016/j.bioactmat.2025.05.021Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effectsXiaoyang Liu0Jia Dong1Zhongshu Wu2Jiarong Cui3Yixin Zheng4Min Zhou5Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310009, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining, 314400, ChinaZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, ChinaZhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, ChinaInstitute of Translational Medicine, Zhejiang University, Hangzhou, 310009, ChinaThe First affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaEye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China; Institute of Translational Medicine, Zhejiang University, Hangzhou, 310009, China; Zhejiang University-University of Edinburgh Institute (ZJU-UoE Institute), Zhejiang University School of Medicine, Zhejiang University, Haining, 314400, China; Zhejiang University-Ordos City Etuoke Banner Joint Research Center, Zhejiang University, Haining, 314400, China; Research Center for Life Science and Human Health, Binjiang Institute of Zhejiang University, Zhejiang University, Hangzhou, 310053, China; State Key Laboratory of Transvascular Implantation Devices, Zhejiang University, Hangzhou, 310009, China; Corresponding author. Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.Gouty arthritis (GA) is a type of inflammatory arthritis caused by the deposition of monosodium urate crystals. Current clinical therapies fail to simultaneously reduce uric acid (UA) levels and alleviate inflammation. Previous studies have demonstrated that Euglena (Eug) polysaccharides can effectively adsorb UA. Colchicine (Col), the most prescribed medication for GA, exhibits anti-inflammatory effects but is associated with significant side effects. Here, we developed an oral microalgae-based hydrogel system (Eug-Col@Fucar) utilizing Fucar to load the Eug-Col complex, aiming to synergistically reduce UA levels and alleviate inflammation in GA treatment. Eug-Col@Fucar regulated release characteristics and enhanced intestinal retention, thereby mitigating the side effects associated with oral Col. The oral administration of Eug-Col@Fucar could inhibit the progression of GA by eliminating reactive oxygen species, reprogramming the inflammatory microenvironment to promote cell polarization towards M2-like anti-inflammatory cells, inhibiting the NLRP3-IL-1β pathway, and reducing the expression of pro-inflammatory factors. Additionally, Eug-Col@Fucar improved bile acid metabolism in vivo, alleviating the intestinal-hepatic circulation damage caused by Col. This study presents a safe, simple, and highly effective treatment strategy for managing GA and alleviating the gastrointestinal side effects that arise from the long-term administration of Col, demonstrating clinical practicability.http://www.sciencedirect.com/science/article/pii/S2452199X25002154MicroalgaeDrug deliveryColchicineGouty arthritisUric acidAnti-inflammation |
| spellingShingle | Xiaoyang Liu Jia Dong Zhongshu Wu Jiarong Cui Yixin Zheng Min Zhou Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects Bioactive Materials Microalgae Drug delivery Colchicine Gouty arthritis Uric acid Anti-inflammation |
| title | Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects |
| title_full | Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects |
| title_fullStr | Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects |
| title_full_unstemmed | Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects |
| title_short | Microalgae-based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects |
| title_sort | microalgae based hydrogel drug delivery system for treatment of gouty arthritis with alleviated colchicine side effects |
| topic | Microalgae Drug delivery Colchicine Gouty arthritis Uric acid Anti-inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25002154 |
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