Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system.
Liposils, synthesized via the liposome templating method, offer a promising strategy for enhancing liposome stability by employing a silica coating. This study focuses on the development of nanocarriers utilizing silica-coated nanoliposomes for encapsulating the poorly water-soluble drug, ibrutinib....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0310492 |
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| author | Fareeaa Ashar Asif Ansari Shaik Mohammed S Selvamuthukumar |
| author_facet | Fareeaa Ashar Asif Ansari Shaik Mohammed S Selvamuthukumar |
| author_sort | Fareeaa Ashar |
| collection | DOAJ |
| description | Liposils, synthesized via the liposome templating method, offer a promising strategy for enhancing liposome stability by employing a silica coating. This study focuses on the development of nanocarriers utilizing silica-coated nanoliposomes for encapsulating the poorly water-soluble drug, ibrutinib. Ibrutinib-loaded nanoliposomes were meticulously formulated using the reverse-phase evaporation technique, serving as templates for silica coating, resulting in spherical liposils with an average size of approximately 240 nanometers. Comprehensive characterization of the liposil's physical and chemical properties was conducted using various analytical methods, including dynamic light scattering, transmission electron microscopy, Fourier-transform infrared spectroscopy, and X-ray diffraction analysis. Liposils demonstrated superior performance compared to ibrutinib-loaded nanoliposomes, showing sustained drug release profiles in simulated intestinal fluids and resistance to simulated gastric fluid, as confirmed by dissolution studies. Moreover, ibrutinib liposils exhibited a significant increase in half-life (4.08-fold) and notable improvement in bioavailability (3.12-fold) compared to ibrutinib suspensions, as determined by pharmacokinetic studies in rats. These findings underscore the potential of liposils as nanocarriers for orally delivering poorly water-soluble drugs, offering enhanced stability and controlled release profiles, thereby improving bioavailability prospects and therapeutic efficacy. This approach holds promise for addressing challenges associated with the oral administration of drugs with limited solubility, thereby advancing drug delivery technologies and clinical outcomes in pharmaceutical research and development. |
| format | Article |
| id | doaj-art-dcf6f32b9f0a420fbcf25c291f3268f8 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-dcf6f32b9f0a420fbcf25c291f3268f82024-12-13T05:31:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01199e031049210.1371/journal.pone.0310492Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system.Fareeaa AsharAsif Ansari Shaik MohammedS SelvamuthukumarLiposils, synthesized via the liposome templating method, offer a promising strategy for enhancing liposome stability by employing a silica coating. This study focuses on the development of nanocarriers utilizing silica-coated nanoliposomes for encapsulating the poorly water-soluble drug, ibrutinib. Ibrutinib-loaded nanoliposomes were meticulously formulated using the reverse-phase evaporation technique, serving as templates for silica coating, resulting in spherical liposils with an average size of approximately 240 nanometers. Comprehensive characterization of the liposil's physical and chemical properties was conducted using various analytical methods, including dynamic light scattering, transmission electron microscopy, Fourier-transform infrared spectroscopy, and X-ray diffraction analysis. Liposils demonstrated superior performance compared to ibrutinib-loaded nanoliposomes, showing sustained drug release profiles in simulated intestinal fluids and resistance to simulated gastric fluid, as confirmed by dissolution studies. Moreover, ibrutinib liposils exhibited a significant increase in half-life (4.08-fold) and notable improvement in bioavailability (3.12-fold) compared to ibrutinib suspensions, as determined by pharmacokinetic studies in rats. These findings underscore the potential of liposils as nanocarriers for orally delivering poorly water-soluble drugs, offering enhanced stability and controlled release profiles, thereby improving bioavailability prospects and therapeutic efficacy. This approach holds promise for addressing challenges associated with the oral administration of drugs with limited solubility, thereby advancing drug delivery technologies and clinical outcomes in pharmaceutical research and development.https://doi.org/10.1371/journal.pone.0310492 |
| spellingShingle | Fareeaa Ashar Asif Ansari Shaik Mohammed S Selvamuthukumar Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. PLoS ONE |
| title | Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. |
| title_full | Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. |
| title_fullStr | Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. |
| title_full_unstemmed | Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. |
| title_short | Enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system. |
| title_sort | enhancement of oral bioavailability of ibrutinib using a liposil nanohybrid delivery system |
| url | https://doi.org/10.1371/journal.pone.0310492 |
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