Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice
Optoacoustic (OA) tomography is a powerful noninvasive preclinical imaging tool enabling high resolution whole-body visualization of biodistribution and dynamics of molecular agents. The technique yet lacks endogenous soft-tissue contrast, which often hampers anatomical navigation. Herein, we devise...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Photoacoustics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597924000764 |
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| author | Sandeep Kumar Kalva Ali Özbek Michael Reiss Xosé Luís Deán-Ben Daniel Razansky |
| author_facet | Sandeep Kumar Kalva Ali Özbek Michael Reiss Xosé Luís Deán-Ben Daniel Razansky |
| author_sort | Sandeep Kumar Kalva |
| collection | DOAJ |
| description | Optoacoustic (OA) tomography is a powerful noninvasive preclinical imaging tool enabling high resolution whole-body visualization of biodistribution and dynamics of molecular agents. The technique yet lacks endogenous soft-tissue contrast, which often hampers anatomical navigation. Herein, we devise spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography for concurrent OA and pulse-echo ultrasound (US) imaging of whole mice. To this end, a spherical array transducer featuring a central curvilinear segment is employed. Full rotation of the array renders transverse US and OA views, while additional translation facilitates volumetric whole-body imaging with high spatial resolution down to 150 µm and 110 µm in the OA and US modes, respectively. OA imaging revealed blood-filled, vascular organs like heart, liver, spleen, kidneys, and surrounding vasculature, whilst complementary details of bones, lungs, and skin boundaries were provided by the US. The dual-modal capability of SVOPUS for label-free imaging of tissue morphology and function is poised to facilitate pharmacokinetic studies, disease monitoring, and image-guided therapies. |
| format | Article |
| id | doaj-art-dca6518c504b44b09ca19fd5eb7311d6 |
| institution | Kabale University |
| issn | 2213-5979 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj-art-dca6518c504b44b09ca19fd5eb7311d62024-11-20T05:06:56ZengElsevierPhotoacoustics2213-59792024-12-0140100659Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of miceSandeep Kumar Kalva0Ali Özbek1Michael Reiss2Xosé Luís Deán-Ben3Daniel Razansky4Institute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich CH-8057, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich CH-8093, Switzerland; Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, IndiaInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich CH-8057, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich CH-8093, SwitzerlandInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich CH-8057, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich CH-8093, SwitzerlandInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich CH-8057, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich CH-8093, SwitzerlandInstitute of Pharmacology and Toxicology and Institute for Biomedical Engineering, Faculty of Medicine, University of Zurich, Zurich CH-8057, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zurich, Zurich CH-8093, Switzerland; Correspondence to: Institute of Biomedical Engineering, University of Zurich and ETH Zurich, HIT E42.1, Wolfgang-Pauli-Strasse 27, Zurich CH-8093, Switzerland.Optoacoustic (OA) tomography is a powerful noninvasive preclinical imaging tool enabling high resolution whole-body visualization of biodistribution and dynamics of molecular agents. The technique yet lacks endogenous soft-tissue contrast, which often hampers anatomical navigation. Herein, we devise spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography for concurrent OA and pulse-echo ultrasound (US) imaging of whole mice. To this end, a spherical array transducer featuring a central curvilinear segment is employed. Full rotation of the array renders transverse US and OA views, while additional translation facilitates volumetric whole-body imaging with high spatial resolution down to 150 µm and 110 µm in the OA and US modes, respectively. OA imaging revealed blood-filled, vascular organs like heart, liver, spleen, kidneys, and surrounding vasculature, whilst complementary details of bones, lungs, and skin boundaries were provided by the US. The dual-modal capability of SVOPUS for label-free imaging of tissue morphology and function is poised to facilitate pharmacokinetic studies, disease monitoring, and image-guided therapies.http://www.sciencedirect.com/science/article/pii/S2213597924000764Optoacoustic imagingPhotoacousticsSmall animal imagingUltrasonographyUltrasonic transducers |
| spellingShingle | Sandeep Kumar Kalva Ali Özbek Michael Reiss Xosé Luís Deán-Ben Daniel Razansky Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice Photoacoustics Optoacoustic imaging Photoacoustics Small animal imaging Ultrasonography Ultrasonic transducers |
| title | Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice |
| title_full | Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice |
| title_fullStr | Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice |
| title_full_unstemmed | Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice |
| title_short | Spiral volumetric optoacoustic and ultrasound (SVOPUS) tomography of mice |
| title_sort | spiral volumetric optoacoustic and ultrasound svopus tomography of mice |
| topic | Optoacoustic imaging Photoacoustics Small animal imaging Ultrasonography Ultrasonic transducers |
| url | http://www.sciencedirect.com/science/article/pii/S2213597924000764 |
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