FAP-CAR-T cells reduce dystrophic muscle fibrosis, improving adeno-associated virus gene transfer efficacy

FAP-CAR-T cells reduce dystrophic muscle fibrosis, improving adeno-associated virus gene transfer efficacy

Tissue fibrosis is a pathological feature of many diseases including muscular dystrophies such as Duchenne muscular dystrophy (DMD). Fibrosis may limit the effectiveness of gene therapy in muscle impacting on viral dosing but direct evidence is lacking. Strategies to reduce skeletal muscle fibrosis...

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Bibliographic Details
Main Authors: Maxime Ferrand, Céline J. Rocca, Guillaume Corre, Valentina Buffa, Sophie Frin, Francine Garnache-Ottou, Elodie Bôle-Richard, Sonia Albini, Isabelle Richard, Anne Galy
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
fibrosis
immunotherapy
muscular dystrophy
AAV
CAR-T cells
scRNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125001408
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http://www.sciencedirect.com/science/article/pii/S2329050125001408

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