Lysosomal gene ATP6AP1 promotes doxorubicin resistance via up-regulating autophagic flux in breast cancer

Lysosomal gene ATP6AP1 promotes doxorubicin resistance via up-regulating autophagic flux in breast cancer

Abstract Background Breast cancer remains the most prevalent malignancy in women. Chemotherapy is the primary systemic treatment modality, and the effectiveness of treatment is often hampered by chemoresistance. Autophagy has been implicated in promoting chemoresistance, as elevated autophagic flux...

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Bibliographic Details
Main Authors: Yinjiao Fei, Xueqin Yan, Mingxing Liang, Shu Zhou, Di Xu, Lei Li, Weilin Xu, Yuxin Song, Zhen Zhu, Jian Zhang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
Breast cancer
Doxorubicin
ATP6AP1
Autophagy
Chemoresistance
Online Access:https://doi.org/10.1186/s12935-024-03579-9
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