Novel NO-TZDs and trimethoxychalcone-based DHPMs: design, synthesis, and biological evaluation as potential VEGFR-2 inhibitors

Novel NO-TZDs and trimethoxychalcone-based DHPMs: design, synthesis, and biological evaluation as potential VEGFR-2 inhibitors

Novel series of nitric oxide-releasing thiazolidine-2,4-diones (NO-TZD-3a-d,5,6) and 3,4,5-trimethoxychalcone-based multifunctional 1,4-dihydropyrimidines (CDHPM-10a-g) have been designed and synthesised as potent broad-spectrum anticancer agents with potential VEGFR-2 inhibition. The designed analo...

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Bibliographic Details
Main Authors: Mater H. Mahnashi, Mohammed Nahari, Hassan Almasoudi, Abdulaziz Alhasaniah, Sara Elgazwi, Mahrous A. Abou-Salim
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
NO-TZD
3,4,5-trimethoxychalcone
1,4-dihydropyrimidine
OpenEye
five-dose
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2358934
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