Investigation of newborn blood metabolomics in varying intrauterine growth conditions
Objectives: This study aimed to investigate changes in the blood metabolic profiles of newborns with varying intrauterine growth conditions. Specifically, we analyzed the levels of amino acids, carnitine, and succinylacetone among full-term newborns, including small for gestational age (SGA), approp...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Jornal de Pediatria |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755724001025 |
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| author | Shengwen Wang Xiaofei Lin Yu Zhou Xin Yang Mingming Ou Linxin Zhang Yumei Wang Jing Gao |
| author_facet | Shengwen Wang Xiaofei Lin Yu Zhou Xin Yang Mingming Ou Linxin Zhang Yumei Wang Jing Gao |
| author_sort | Shengwen Wang |
| collection | DOAJ |
| description | Objectives: This study aimed to investigate changes in the blood metabolic profiles of newborns with varying intrauterine growth conditions. Specifically, we analyzed the levels of amino acids, carnitine, and succinylacetone among full-term newborns, including small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). We aim to identify differential metabolites and metabolic pathways that may offer insights into clinical interventions. Methods: A total of 5106 full-term newborns were included in the study. Blood samples were obtained from all newborns between 3 and 5 days after birth and analyzed using tandem mass spectrometry to detect blood metabolites. Subsequently, we screened for different metabolites and metabolic pathways among the groups using the MetaboAnalystR package (Version 1.0.1) in R software (R-3.6.0). Results: The levels of blood amino acids and carnitine metabolism differed significantly among newborns with varying intrauterine growth conditions. Full-term SGA newborns exhibited a decrease in multiple amino acids and an increase in multiple carnitines, while full-term LGA newborns showed an increase in multiple amino acids and acylcarnitines. Conclusion: Continuous monitoring of the short-term and long-term growth and metabolic status of full-term SGA and LGA newborns is warranted with individualized dietary and nutritional adjustments to promote healthy growth in a timely manner. The findings of this research contribute to the broader understanding of SGA/LGA and shall inform future research on metabolomics, interventions, and long-term outcomes. |
| format | Article |
| id | doaj-art-dc60c0b3c9704cf2a1c7c38322a84141 |
| institution | Kabale University |
| issn | 0021-7557 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj-art-dc60c0b3c9704cf2a1c7c38322a841412025-01-04T04:55:48ZengElsevierJornal de Pediatria0021-75572025-01-0110117481Investigation of newborn blood metabolomics in varying intrauterine growth conditionsShengwen Wang0Xiaofei Lin1Yu Zhou2Xin Yang3Mingming Ou4Linxin Zhang5Yumei Wang6Jing Gao7Huai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Department of Children's Rehabilitation, Jiangsu Province, ChinaHuai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Department of Pediatrics, Jiangsu Province, ChinaHuai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Department of Children's Rehabilitation, Jiangsu Province, ChinaHuai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Neonatal Disease Screening Center, Jiangsu Province, ChinaHuai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Neonatal Disease Screening Center, Jiangsu Province, ChinaHuai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Neonatal Disease Screening Center, Jiangsu Province, ChinaHuai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Neonatal Disease Screening Center, Jiangsu Province, China; Corresponding author.Huai'an Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Department of Children's Rehabilitation, Jiangsu Province, ChinaObjectives: This study aimed to investigate changes in the blood metabolic profiles of newborns with varying intrauterine growth conditions. Specifically, we analyzed the levels of amino acids, carnitine, and succinylacetone among full-term newborns, including small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). We aim to identify differential metabolites and metabolic pathways that may offer insights into clinical interventions. Methods: A total of 5106 full-term newborns were included in the study. Blood samples were obtained from all newborns between 3 and 5 days after birth and analyzed using tandem mass spectrometry to detect blood metabolites. Subsequently, we screened for different metabolites and metabolic pathways among the groups using the MetaboAnalystR package (Version 1.0.1) in R software (R-3.6.0). Results: The levels of blood amino acids and carnitine metabolism differed significantly among newborns with varying intrauterine growth conditions. Full-term SGA newborns exhibited a decrease in multiple amino acids and an increase in multiple carnitines, while full-term LGA newborns showed an increase in multiple amino acids and acylcarnitines. Conclusion: Continuous monitoring of the short-term and long-term growth and metabolic status of full-term SGA and LGA newborns is warranted with individualized dietary and nutritional adjustments to promote healthy growth in a timely manner. The findings of this research contribute to the broader understanding of SGA/LGA and shall inform future research on metabolomics, interventions, and long-term outcomes.http://www.sciencedirect.com/science/article/pii/S0021755724001025MetabolomicsSmall for gestational ageLarge for gestational ageAmino acidCarnitine |
| spellingShingle | Shengwen Wang Xiaofei Lin Yu Zhou Xin Yang Mingming Ou Linxin Zhang Yumei Wang Jing Gao Investigation of newborn blood metabolomics in varying intrauterine growth conditions Jornal de Pediatria Metabolomics Small for gestational age Large for gestational age Amino acid Carnitine |
| title | Investigation of newborn blood metabolomics in varying intrauterine growth conditions |
| title_full | Investigation of newborn blood metabolomics in varying intrauterine growth conditions |
| title_fullStr | Investigation of newborn blood metabolomics in varying intrauterine growth conditions |
| title_full_unstemmed | Investigation of newborn blood metabolomics in varying intrauterine growth conditions |
| title_short | Investigation of newborn blood metabolomics in varying intrauterine growth conditions |
| title_sort | investigation of newborn blood metabolomics in varying intrauterine growth conditions |
| topic | Metabolomics Small for gestational age Large for gestational age Amino acid Carnitine |
| url | http://www.sciencedirect.com/science/article/pii/S0021755724001025 |
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