Hemoadsorption improves kidney microcirculatory oxygenation and oxygen consumption, ameliorates tubular injury, and improves kidney function in a rat model of sepsis-induced AKI

Hemoadsorption improves kidney microcirculatory oxygenation and oxygen consumption, ameliorates tubular injury, and improves kidney function in a rat model of sepsis-induced AKI

Abstract Microcirculatory dysfunction, hypoxia, and inflammation are considered to be central in the pathogenesis of sepsis-induced acute kidney injury (AKI). In this experimental study, we hypothesized that extracorporeal removal of inflammatory cytokines by hemoadsorption (HA) therapy may mitigate...

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Bibliographic Details
Main Authors: Bülent Ergin, Deniz Erol Kutucu, Aysegul Kapucu, Wijnie van Dam, Lorenza Moretto, Paul Heyman, Can Ince
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
AKI
Renal oxygenation
Renal perfusion
Tissue damage,
Sepsis
Hemoadsorption
Online Access:https://doi.org/10.1038/s41598-024-79997-6
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