AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma
Immune checkpoint inhibitors (ICIs) become integral in clinical practice, yet their application in cancer therapy is constrained by low overall response rates and the primary resistance of cancers to ICIs. Herein, this study proposes aggregation-induced emission (AIE)-based nanoparticles (NPs) for a...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004484 |
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| author | Lu Li Qing Xu Xiuzhen Zhang Yuan Jiang La Zhang Jiao Guo Haichuan Liu Bin Jiang Shenglong Li Qiling Peng Ning Jiang Jianwei Wang |
| author_facet | Lu Li Qing Xu Xiuzhen Zhang Yuan Jiang La Zhang Jiao Guo Haichuan Liu Bin Jiang Shenglong Li Qiling Peng Ning Jiang Jianwei Wang |
| author_sort | Lu Li |
| collection | DOAJ |
| description | Immune checkpoint inhibitors (ICIs) become integral in clinical practice, yet their application in cancer therapy is constrained by low overall response rates and the primary resistance of cancers to ICIs. Herein, this study proposes aggregation-induced emission (AIE)-based nanoparticles (NPs) for a more effective and synergistic approach combining immunotherapy and photodynamic therapy (PDT) to achieve higher responses than anti-PD-L1 monotherapy. The TBP@aPD-L1 NPs are constructed by functionalizing azide group-modified TBP-2 (TBP-N3) with anti-PD-L1 antibodies via the DBCO-S-S-PEG2000-COOH linker. The anti-PD-L1 target the tumor cells and promote the TBP-N3 accumulation in tumors for enhanced PDT. Notably, the TBP-N3, featuring aggregation-induced emission, boosts reactive oxygen species (ROS) generation through both type I and type II processes for enhanced PDT. The TBP@aPD-L1-mediated PDT induces more powerful effects of direct tumor cell-killing and further elicits effective immunogenic cell death (ICD), which exerts anti-tumor immunity by activating T cells for ICI treatment and reshapes the tumor immune microenvironment (TIME), thereby enhancing the efficacy of PD-L1 blockade of anti-PD-L1. Consequently, TBP@aPD-L1 NPs demonstrated significantly enhanced inhibition of tumor growth in the mouse model of malignant melanoma (MM). Our NPs act as a facile and effective drug delivery platform for enhanced immunotherapy combined with enhanced PDT in treating MM. |
| format | Article |
| id | doaj-art-dc40432e96de4ade8bfe00c29466924e |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-dc40432e96de4ade8bfe00c29466924e2025-01-17T04:52:04ZengElsevierMaterials Today Bio2590-00642025-02-0130101387AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanomaLu Li0Qing Xu1Xiuzhen Zhang2Yuan Jiang3La Zhang4Jiao Guo5Haichuan Liu6Bin Jiang7Shenglong Li8Qiling Peng9Ning Jiang10Jianwei Wang11Department of Immunology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR ChinaDepartment of Immunology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR ChinaHunan University of Medicine General Hospital, Hunan, 418000, PR ChinaDepartment of Immunology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR ChinaDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR ChinaSchool of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR ChinaSchool of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR ChinaSchool of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR ChinaSchool of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR China; Corresponding author. School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR China.Bijie Municipal Health Bureau, Guizhou, 551700, PR China; Corresponding author. Bijie Municipal Health Bureau, Guizhou, 551700, PR China.Department of Pathology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR China; Molecular Medicine Diagnostic and Testing Center, Chongqing Medical University, Chongqing, 400016, PR China; Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China; Corresponding author. Department of Pathology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR China.Department of Immunology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR China; Corresponding author. Department of Immunology, School of Basic Medical Science, Chongqing Medical University, Chongqing, 400016, PR China.Immune checkpoint inhibitors (ICIs) become integral in clinical practice, yet their application in cancer therapy is constrained by low overall response rates and the primary resistance of cancers to ICIs. Herein, this study proposes aggregation-induced emission (AIE)-based nanoparticles (NPs) for a more effective and synergistic approach combining immunotherapy and photodynamic therapy (PDT) to achieve higher responses than anti-PD-L1 monotherapy. The TBP@aPD-L1 NPs are constructed by functionalizing azide group-modified TBP-2 (TBP-N3) with anti-PD-L1 antibodies via the DBCO-S-S-PEG2000-COOH linker. The anti-PD-L1 target the tumor cells and promote the TBP-N3 accumulation in tumors for enhanced PDT. Notably, the TBP-N3, featuring aggregation-induced emission, boosts reactive oxygen species (ROS) generation through both type I and type II processes for enhanced PDT. The TBP@aPD-L1-mediated PDT induces more powerful effects of direct tumor cell-killing and further elicits effective immunogenic cell death (ICD), which exerts anti-tumor immunity by activating T cells for ICI treatment and reshapes the tumor immune microenvironment (TIME), thereby enhancing the efficacy of PD-L1 blockade of anti-PD-L1. Consequently, TBP@aPD-L1 NPs demonstrated significantly enhanced inhibition of tumor growth in the mouse model of malignant melanoma (MM). Our NPs act as a facile and effective drug delivery platform for enhanced immunotherapy combined with enhanced PDT in treating MM.http://www.sciencedirect.com/science/article/pii/S2590006424004484Immune checkpoint inhibitorsAggregation-induced emissionPhotodynamic therapiesImmunogenic cell deathMalignant melanoma |
| spellingShingle | Lu Li Qing Xu Xiuzhen Zhang Yuan Jiang La Zhang Jiao Guo Haichuan Liu Bin Jiang Shenglong Li Qiling Peng Ning Jiang Jianwei Wang AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma Materials Today Bio Immune checkpoint inhibitors Aggregation-induced emission Photodynamic therapies Immunogenic cell death Malignant melanoma |
| title | AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma |
| title_full | AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma |
| title_fullStr | AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma |
| title_full_unstemmed | AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma |
| title_short | AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma |
| title_sort | aiegen self assembled nanoparticles with anti pd l1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma |
| topic | Immune checkpoint inhibitors Aggregation-induced emission Photodynamic therapies Immunogenic cell death Malignant melanoma |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004484 |
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