Mechanisms of Immune Evasion in PTEN Loss Prostate Cancer

Mechanisms of Immune Evasion in PTEN Loss Prostate Cancer

<i>PTEN</i> (phosphatase and tensin homolog) is a frequently lost tumor suppressor gene in prostate cancer, leading to aggressive tumor behavior and poor clinical outcomes. <i>PTEN</i> loss results in aberrant activation of the PI3K/AKT/mTOR pathway, promoting oncogenesis. Th...

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Bibliographic Details
Main Authors: Jorge Esteban-Villarrubia, Pablo Alvarez Ballesteros, Miguel Martín-Serrano, María Ruiz Vico, Juan M Funes, Guillermo de Velasco, Elena Castro, David Olmos, Daniel Castellano, Enrique González-Billalabeitia
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Immuno
Subjects:
prostate cancer
<i>PTEN</i> loss
immune evasion
immunotherapy
Online Access:https://www.mdpi.com/2673-5601/4/4/28
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Summary:<i>PTEN</i> (phosphatase and tensin homolog) is a frequently lost tumor suppressor gene in prostate cancer, leading to aggressive tumor behavior and poor clinical outcomes. <i>PTEN</i> loss results in aberrant activation of the PI3K/AKT/mTOR pathway, promoting oncogenesis. These alterations also lead to an immunosuppressive tumor microenvironment with altered immune cell infiltration, cytokine profiles, and immune checkpoint regulation. This review aims to provide a comprehensive overview of the mechanisms underlying <i>PTEN</i> loss in prostate cancer and the consequent immune alterations observed in this subtype, thus underscoring the importance of understanding <i>PTEN</i>-mediated immune modulation for the development of effective therapeutic interventions in prostate cancer.
ISSN:2673-5601

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