A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin
In the present study, a partial least square regression (PLSR) was applied to Fourier-transform infrared (FTIR) data for rapid and direct quantification of a quinolone family antibiotic moxifloxacin and the proposed method was counter validated by reverse-phase high-performance liquid chromatography...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/jspe/6448992 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849330558262312960 |
|---|---|
| author | Muhammad Umair Kamal Sumia Akram Muhammad Ahmad Khan Atique Ur Rehman Muhammad Ehsan Ameer Raja Adil Sarfraz Asif Iqbal Rizwan Ashraf Muhammad Mushtaq |
| author_facet | Muhammad Umair Kamal Sumia Akram Muhammad Ahmad Khan Atique Ur Rehman Muhammad Ehsan Ameer Raja Adil Sarfraz Asif Iqbal Rizwan Ashraf Muhammad Mushtaq |
| author_sort | Muhammad Umair Kamal |
| collection | DOAJ |
| description | In the present study, a partial least square regression (PLSR) was applied to Fourier-transform infrared (FTIR) data for rapid and direct quantification of a quinolone family antibiotic moxifloxacin and the proposed method was counter validated by reverse-phase high-performance liquid chromatography under diode array detection (RP-HPLC-DAD). The PLSR-based processing of FTIR spectra of moxifloxacin standards and formulations disclosed a concentration-dependent mid-IR region at 1456 cm−1. The FTIR-based assay method was validated in accordance with the International Conference on Harmonization (ICH) guidelines and was found to be linear over the concentration range of 0.1 mg/mg–1.0 mg/mg (w/w) of solid mixtures with a coefficient of determination (R2) of 0.9951. Moreover, the results when counter validated by RP-HPLC-DAD were found to be concordant (RSD ≤ 2%). The analysis of moxifloxacin quality control samples through the developed FTIR assay offered overall recovery rates equals to 97.61%–103.74%. The real-time analysis of moxifloxacin formulations marketed in Pakistan authenticated the presence of active pharmaceutical ingredients (APIs) within the claimed ranges. We can eventually conclude that FTIR spectroscopy if coupled with a suitable data-processing scheme can provide more expedient, rapid, and economical choice for the direct quantification of moxifloxacin API and its formulations. |
| format | Article |
| id | doaj-art-dbfd4001afc24085ad3bc821fda5b8a8 |
| institution | Kabale University |
| issn | 2314-4939 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-dbfd4001afc24085ad3bc821fda5b8a82025-08-20T03:46:53ZengWileyJournal of Spectroscopy2314-49392025-01-01202510.1155/jspe/6448992A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for MoxifloxacinMuhammad Umair Kamal0Sumia Akram1Muhammad Ahmad Khan2Atique Ur Rehman3Muhammad Ehsan Ameer4Raja Adil Sarfraz5Asif Iqbal6Rizwan Ashraf7Muhammad Mushtaq8Department of ChemistryDivision of Science and TechnologyDepartment of ChemistryUniversity of Child Heath Science LahoreDepartment of ChemistryDepartment of ChemistryDepartment of ChemistryDepartment of ChemistryDepartment of ChemistryIn the present study, a partial least square regression (PLSR) was applied to Fourier-transform infrared (FTIR) data for rapid and direct quantification of a quinolone family antibiotic moxifloxacin and the proposed method was counter validated by reverse-phase high-performance liquid chromatography under diode array detection (RP-HPLC-DAD). The PLSR-based processing of FTIR spectra of moxifloxacin standards and formulations disclosed a concentration-dependent mid-IR region at 1456 cm−1. The FTIR-based assay method was validated in accordance with the International Conference on Harmonization (ICH) guidelines and was found to be linear over the concentration range of 0.1 mg/mg–1.0 mg/mg (w/w) of solid mixtures with a coefficient of determination (R2) of 0.9951. Moreover, the results when counter validated by RP-HPLC-DAD were found to be concordant (RSD ≤ 2%). The analysis of moxifloxacin quality control samples through the developed FTIR assay offered overall recovery rates equals to 97.61%–103.74%. The real-time analysis of moxifloxacin formulations marketed in Pakistan authenticated the presence of active pharmaceutical ingredients (APIs) within the claimed ranges. We can eventually conclude that FTIR spectroscopy if coupled with a suitable data-processing scheme can provide more expedient, rapid, and economical choice for the direct quantification of moxifloxacin API and its formulations.http://dx.doi.org/10.1155/jspe/6448992 |
| spellingShingle | Muhammad Umair Kamal Sumia Akram Muhammad Ahmad Khan Atique Ur Rehman Muhammad Ehsan Ameer Raja Adil Sarfraz Asif Iqbal Rizwan Ashraf Muhammad Mushtaq A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin Journal of Spectroscopy |
| title | A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin |
| title_full | A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin |
| title_fullStr | A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin |
| title_full_unstemmed | A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin |
| title_short | A Fourier-Transform Infrared Spectroscopy-Based Simple, Rapid, and Direct Quantification Assay for Moxifloxacin |
| title_sort | fourier transform infrared spectroscopy based simple rapid and direct quantification assay for moxifloxacin |
| url | http://dx.doi.org/10.1155/jspe/6448992 |
| work_keys_str_mv | AT muhammadumairkamal afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT sumiaakram afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadahmadkhan afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT atiqueurrehman afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadehsanameer afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT rajaadilsarfraz afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT asifiqbal afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT rizwanashraf afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadmushtaq afouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadumairkamal fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT sumiaakram fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadahmadkhan fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT atiqueurrehman fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadehsanameer fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT rajaadilsarfraz fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT asifiqbal fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT rizwanashraf fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin AT muhammadmushtaq fouriertransforminfraredspectroscopybasedsimplerapidanddirectquantificationassayformoxifloxacin |