SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice

SPECT/CT imaging of EGFR-positive head and neck squamous cell carcinoma patient-derived xenografts with 203Pb-PSC-panitumumab in NRG mice

Abstract Background The objective of this research was the development and evaluation of 203Pb-labelled panitumumab (203Pb-PSC-panitumumab) as an immuno-SPECT radioligand for the detection of EGFR + head and neck squamous cell carcinoma (HNSCC) in a patient-derived xenograft (PDX) mouse model. The 5...

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Bibliographic Details
Main Authors: Nasim Sarrami, Bryce Nelson, Samantha Leier, John Wilson, Conrad Chan, Jalna Meens, Teesha Komal, Laurie Ailles, Melinda Wuest, Michael Schultz, Afsaneh Lavasanifar, Raymond M. Reilly, Frank Wuest
Format: Article
Language:English
Published: SpringerOpen 2024-11-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Panitumumab
Pb-203
Single-Photon Emission Computed Tomography (SPECT)
Epidermal growth factor receptor (EGFR)
Radiotheranostics
Pb-212
Online Access:https://doi.org/10.1186/s41181-024-00313-8
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