Brain Organoids: Studying Human Brain Development and Diseases in a Dish
With the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human neurodevelopment and neurological disorders. Brain organoids are stem-cell-derived 3D suspension cultures that self-assemble into an organized...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/5902824 |
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| _version_ | 1850167079462764544 |
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| author | Jie Xu Zhexing Wen |
| author_facet | Jie Xu Zhexing Wen |
| author_sort | Jie Xu |
| collection | DOAJ |
| description | With the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human neurodevelopment and neurological disorders. Brain organoids are stem-cell-derived 3D suspension cultures that self-assemble into an organized structure with cell types and cytoarchitectures recapitulating the developing brain. In recent years, brain organoids have been utilized in various aspects, ranging from basic biology studies, to disease modeling, and high-throughput screening of pharmaceutical compounds. In this review, we overview the establishment and development of brain organoid technology, its recent progress, and translational applications, as well as existing limitations and future directions. |
| format | Article |
| id | doaj-art-dbd68c9dfd4e42cfa6adf82c7cffc6be |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-dbd68c9dfd4e42cfa6adf82c7cffc6be2025-08-20T02:21:17ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/59028245902824Brain Organoids: Studying Human Brain Development and Diseases in a DishJie Xu0Zhexing Wen1The Graduate Program in Genetics and Molecular Biology, Laney Graduate School, Emory University, GA 30322, USADepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USAWith the rapid development of stem cell technology, the advent of three-dimensional (3D) cultured brain organoids has opened a new avenue for studying human neurodevelopment and neurological disorders. Brain organoids are stem-cell-derived 3D suspension cultures that self-assemble into an organized structure with cell types and cytoarchitectures recapitulating the developing brain. In recent years, brain organoids have been utilized in various aspects, ranging from basic biology studies, to disease modeling, and high-throughput screening of pharmaceutical compounds. In this review, we overview the establishment and development of brain organoid technology, its recent progress, and translational applications, as well as existing limitations and future directions.http://dx.doi.org/10.1155/2021/5902824 |
| spellingShingle | Jie Xu Zhexing Wen Brain Organoids: Studying Human Brain Development and Diseases in a Dish Stem Cells International |
| title | Brain Organoids: Studying Human Brain Development and Diseases in a Dish |
| title_full | Brain Organoids: Studying Human Brain Development and Diseases in a Dish |
| title_fullStr | Brain Organoids: Studying Human Brain Development and Diseases in a Dish |
| title_full_unstemmed | Brain Organoids: Studying Human Brain Development and Diseases in a Dish |
| title_short | Brain Organoids: Studying Human Brain Development and Diseases in a Dish |
| title_sort | brain organoids studying human brain development and diseases in a dish |
| url | http://dx.doi.org/10.1155/2021/5902824 |
| work_keys_str_mv | AT jiexu brainorganoidsstudyinghumanbraindevelopmentanddiseasesinadish AT zhexingwen brainorganoidsstudyinghumanbraindevelopmentanddiseasesinadish |