Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progressionResearch in context

Integrated single-cell transcriptomic analyses identify a novel lineage plasticity-related cancer cell type involved in prostate cancer progressionResearch in context

Summary: Background: Cancer cell plasticity is the ability of neoplastic cells to alter their identity and acquire new biological properties under microenvironmental pressures. In prostate cancer (PCa), lineage plasticity often results in therapy resistance and trans-differentiation to neuroendocri...

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Bibliographic Details
Main Authors: Faming Zhao, Tingting Zhang, Jinlan Wei, Liang Chen, Zaoqu Liu, Yang Jin, Mingsheng Liu, Hongqing Zhou, Yanxia Hu, Xia Sheng
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:EBioMedicine
Subjects:
Lineage plasticity
Neuroendocrine prostate cancer
Single-cell
LPCs
HMMR
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004341
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