HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells.

HTLV-1 Tax-mediated inhibition of FOXO3a activity is critical for the persistence of terminally differentiated CD4+ T cells.

The mechanisms involved in the persistence of activated CD4+ T lymphocytes following primary human T leukemia/lymphoma virus type 1 (HTLV-1) infection remain unclear. Here, we demonstrate that the HTLV-1 Tax oncoprotein modulates phosphorylation and transcriptional activity of the FOXO3a transcripti...

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Bibliographic Details
Main Authors: David Olagnier, Alexandre Sze, Samar Bel Hadj, Cindy Chiang, Courtney Steel, Xiaoying Han, Jean-Pierre Routy, Rongtuan Lin, John Hiscott, Julien van Grevenynghe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004575&type=printable
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