Mesenchymal stem cell-derived small extracellular vesicles facilitate repair of acute obstruction-induced colonic anastomosis injury by modulating early-stage inflammation in rats

Mesenchymal stem cell-derived small extracellular vesicles facilitate repair of acute obstruction-induced colonic anastomosis injury by modulating early-stage inflammation in rats

Abstract Background Anastomotic leakage (AL), a major complication of colonic anastomoses, leads to prolonged hospital stays and increased mortality. Despite various interventions, AL incidence remains high at approximately 8%. Mesenchymal stem cells-derived small extracellular vesicles (MSCs-sEVs)...

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Bibliographic Details
Main Authors: Zhiwei Dong, Siran Zhou, Xianfeng Xia, Hon-Chi Yip, Kevin Kai-Chung Leung, Melissa Shannon Chan, Philip Wai-Yan Chiu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Small extracellular vesicles
Colonic
Anastomosis
Anastomotic leakage
NF-κB
Online Access:https://doi.org/10.1186/s13287-025-04551-8
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