CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY.
Background: Treatment against hepatitis C virus (HCV) infection based on peginterferon-a (pegIFNa) and ribavirin induces important changes on cytokine release and T cell activation. Objective: Immune response to pegIFNa-ribavirin therapy was explored in patients coinfected by HCV and HIV. Methods:...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2336 |
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| author | Truong Tam Nguyen Reihani Niloofar Pierre-Alain Rubbo Kuster Nils Karine Bollore Jacques Ducos Georges-Philippe Pageaux Jacques Reynes Philippe Van de Perre Edouard Tuaillon |
| author_facet | Truong Tam Nguyen Reihani Niloofar Pierre-Alain Rubbo Kuster Nils Karine Bollore Jacques Ducos Georges-Philippe Pageaux Jacques Reynes Philippe Van de Perre Edouard Tuaillon |
| author_sort | Truong Tam Nguyen |
| collection | DOAJ |
| description | Background: Treatment against hepatitis C virus (HCV) infection based on peginterferon-a (pegIFNa) and ribavirin induces important changes on cytokine release and T cell activation.
Objective: Immune response to pegIFNa-ribavirin therapy was explored in patients coinfected by HCV and HIV.
Methods: Concentrations of 25 cytokines and CD8+ T cell activation were monitored in HCV/HIV coinfected patients classified as sustained virological responders (SVR, n=19) and non-responders (NR, n=11).
Results: High pretreatment concentrations of IP-10 (CXCL-10) and MCP-1 (CCL-2) were associated with poor anti-HCV response. PegIFNa-ribavirin therapy increased CD8+ T cell activation and induced significant changes in levels of eleven cytokines related to both Th1 and Th2 responses in SVR (IL-1b, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-12p40/70, IL-13, IP-10, eotaxin, MCP-1) but only six cytokines in NR (IL-1b, IL-2, IL-5, IL-12p40/70, IL-13, eotaxin). Highest rise in MIP-1b and MCP-1 levels was observed four weeks after anti-HCV treatment initiation in SVR compared to NR (p=0.002 and p=0.03, respectively), whereas a decrease of IL-8 concentration was associated with treatment failure (p= 0.052).
Conclusions: Higher and broader cytokine responses to pegIFNa-ribavirin therapy were observed in SVR patients compared to NR. Changes in IL-8, MIP-1b and MCP-1 serum concentrations may be associated with efficacy of pegIFNa- and ribavirin-based therapies in patients coinfected by HCV and HIV. |
| format | Article |
| id | doaj-art-dbb225ff962d4c51a8152a4da399ec6d |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-dbb225ff962d4c51a8152a4da399ec6d2024-12-02T09:48:25ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062016-01-0180e2016003e201600310.4084/mjhid.2016.0031592CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY.Truong Tam NguyenReihani NiloofarPierre-Alain RubboKuster NilsKarine BolloreJacques DucosGeorges-Philippe PageauxJacques ReynesPhilippe Van de PerreEdouard TuaillonBackground: Treatment against hepatitis C virus (HCV) infection based on peginterferon-a (pegIFNa) and ribavirin induces important changes on cytokine release and T cell activation. Objective: Immune response to pegIFNa-ribavirin therapy was explored in patients coinfected by HCV and HIV. Methods: Concentrations of 25 cytokines and CD8+ T cell activation were monitored in HCV/HIV coinfected patients classified as sustained virological responders (SVR, n=19) and non-responders (NR, n=11). Results: High pretreatment concentrations of IP-10 (CXCL-10) and MCP-1 (CCL-2) were associated with poor anti-HCV response. PegIFNa-ribavirin therapy increased CD8+ T cell activation and induced significant changes in levels of eleven cytokines related to both Th1 and Th2 responses in SVR (IL-1b, IL-1RA, IL-4, IL-5, IL-6, IL-7, IL-12p40/70, IL-13, IP-10, eotaxin, MCP-1) but only six cytokines in NR (IL-1b, IL-2, IL-5, IL-12p40/70, IL-13, eotaxin). Highest rise in MIP-1b and MCP-1 levels was observed four weeks after anti-HCV treatment initiation in SVR compared to NR (p=0.002 and p=0.03, respectively), whereas a decrease of IL-8 concentration was associated with treatment failure (p= 0.052). Conclusions: Higher and broader cytokine responses to pegIFNa-ribavirin therapy were observed in SVR patients compared to NR. Changes in IL-8, MIP-1b and MCP-1 serum concentrations may be associated with efficacy of pegIFNa- and ribavirin-based therapies in patients coinfected by HCV and HIV.http://www.mjhid.org/index.php/mjhid/article/view/2336hepatitis C virus, HIV, cytokines |
| spellingShingle | Truong Tam Nguyen Reihani Niloofar Pierre-Alain Rubbo Kuster Nils Karine Bollore Jacques Ducos Georges-Philippe Pageaux Jacques Reynes Philippe Van de Perre Edouard Tuaillon CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY. Mediterranean Journal of Hematology and Infectious Diseases hepatitis C virus, HIV, cytokines |
| title | CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY. |
| title_full | CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY. |
| title_fullStr | CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY. |
| title_full_unstemmed | CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY. |
| title_short | CYTOKINE RESPONSE ASSOCIATED WITH HEPATITIS C VIRUS CLEARANCE IN HIV COINFECTED PATIENTS INITIATING PEG INTERFERON- BASED THERAPY. |
| title_sort | cytokine response associated with hepatitis c virus clearance in hiv coinfected patients initiating peg interferon based therapy |
| topic | hepatitis C virus, HIV, cytokines |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2336 |
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