Comparative Assessment of the Allergenicity of Hyaluronidases from <i>Polistes dominula</i> (Pol d 2), <i>Vespula vulgaris</i> (Ves v 2), and <i>Apis mellifera</i> Venom (Api m 2)

Comparative Assessment of the Allergenicity of Hyaluronidases from <i>Polistes dominula</i> (Pol d 2), <i>Vespula vulgaris</i> (Ves v 2), and <i>Apis mellifera</i> Venom (Api m 2)

Sensitization to cross-reactive allergens complicates identifying the culprit insect in Hymenoptera venom allergy via diagnostic tests. This study evaluates sensitization to hyaluronidases (Api m 2 from honey bee (<i>Apis mellifera</i>) venom, HBV; Pol d 2 from European paper wasp (<i...

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Main Authors: Johannes Grosch, Bernadette Eberlein, Sebastian Waldherr, Mariona Pascal, Britta Dorn, Clara San Bartolomé, Federico De La Roca Pinzón, Maximilian Schiener, Ulf Darsow, Tilo Biedermann, Jonas Lidholm, Maria Beatrice Bilò, Thilo Jakob, Carsten B. Schmidt-Weber, Simon Blank
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Toxins
Subjects:
allergen cross-reactivity
Api m 2
<i>Apis mellifera</i>
hyaluronidases
Hymenoptera venom allergy
Pol d 2
Online Access:https://www.mdpi.com/2072-6651/16/11/498
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Summary:Sensitization to cross-reactive allergens complicates identifying the culprit insect in Hymenoptera venom allergy via diagnostic tests. This study evaluates sensitization to hyaluronidases (Api m 2 from honey bee (<i>Apis mellifera</i>) venom, HBV; Pol d 2 from European paper wasp (<i>Polistes dominula</i>) venom, PDV; and Ves v 2.0101 and Ves v 2.0201 from yellow jacket (<i>Vespula vulgaris</i>) venom, YJV) and their cross-reactivity in allergic patients from Italy, Spain, and Germany using ImmunoCAPs, ELISA, and basophil activation tests. Sensitization rates were 45% for Api m 2 in HBV-allergic subjects, 25% for Pol d 2 in PDV-allergic individuals, and 20% and 10% for Ves v 2.0201 and Ves v 2.0101 in YJV-allergic patients, respectively. Patients primarily sensitized to Api m 2 showed minimal cross-reactivity to vespid hyaluronidases, whereas those primarily sensitized to Pol d 2 or Ves v 2.0201 exhibited IgE reactivity to Api m 2. Neither Pol d 2 nor Ves v 2.0201 triggered basophil activation. Cross-reactivity of Api m 2, Pol d 2, and Ves v 2.0201 depends on the primary sensitizing venom. Sensitization to Pol d 2 and Ves v 2.0201 remains below 25%, yet these patients may exhibit cross-reactivity to Api m 2. Conversely, HBV-allergic patients sensitized to Api m 2 show minimal reactivity to Pol d 2 or Ves v 2.0201.
ISSN:2072-6651

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